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97534-84-4

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97534-84-4 Usage

Description

(R)-(+)-3-(BENZYLOXYCARBONYL)-4-OXAZOLIDINECARBOXYLIC ACID is a chiral synthon derived from serine, characterized by its white powder form. It is a valuable intermediate in the field of organic chemistry, particularly for the asymmetric synthesis of various nitrogen-containing compounds.

Uses

Used in Pharmaceutical Industry:
(R)-(+)-3-(BENZYLOXYCARBONYL)-4-OXAZOLIDINECARBOXYLIC ACID is used as a chiral building block for the asymmetric synthesis of a wide range of nitrogen-containing pharmaceutical compounds. Its unique stereochemistry allows for the creation of enantiomerically pure products, which is crucial for the development of effective and safe drugs.
Used in Organic Synthesis:
In the field of organic synthesis, (R)-(+)-3-(BENZYLOXYCARBONYL)-4-OXAZOLIDINECARBOXYLIC ACID serves as a versatile chiral synthon, enabling the synthesis of complex nitrogen-containing molecules with high selectivity and yield. This makes it an essential component in the development of novel chemical entities and advanced materials.
Used in Research and Development:
(R)-(+)-3-(BENZYLOXYCARBONYL)-4-OXAZOLIDINECARBOXYLIC ACID is also utilized in research and development settings, where it aids chemists in exploring new synthetic routes and methodologies. Its unique properties and reactivity make it a valuable tool for studying the mechanisms of asymmetric reactions and the development of innovative catalytic systems.

Check Digit Verification of cas no

The CAS Registry Mumber 97534-84-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,7,5,3 and 4 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 97534-84:
(7*9)+(6*7)+(5*5)+(4*3)+(3*4)+(2*8)+(1*4)=174
174 % 10 = 4
So 97534-84-4 is a valid CAS Registry Number.
InChI:InChI=1/C12H13NO5/c14-11(15)10-7-17-8-13(10)12(16)18-6-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H,14,15)/t10-/m1/s1

97534-84-4 Well-known Company Product Price

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  • Alfa Aesar

  • (H27240)  (R)-(+)-3-(Benzyloxycarbonyl)oxazolidine-4-carboxylic acid, 98%   

  • 97534-84-4

  • 1g

  • 399.0CNY

  • Detail
  • Alfa Aesar

  • (H27240)  (R)-(+)-3-(Benzyloxycarbonyl)oxazolidine-4-carboxylic acid, 98%   

  • 97534-84-4

  • 5g

  • 1313.0CNY

  • Detail
  • Aldrich

  • (469475)  (R)-(+)-3-(Benzyloxycarbonyl)-4-oxazolidinecarboxylicacid  98%

  • 97534-84-4

  • 469475-1G

  • 322.92CNY

  • Detail

97534-84-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (R)-(+)-3-(BENZYLOXYCARBONYL)-4-OXAZOLIDINECARBOXYLIC ACID

1.2 Other means of identification

Product number -
Other names (R)-Z-OXAPROLINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:97534-84-4 SDS

97534-84-4Relevant articles and documents

Asymmetric Total Synthesis of (+)-Neooxazolomycin Using a Chirality-Transfer Strategy

Kim, Jae Hyun,Kim, Illan,Song, Yeonghun,Kim, Min Jung,Kim, Sanghee

supporting information, p. 11018 - 11022 (2019/07/17)

The total synthesis of (+)-neooxazolomycin was achieved from the amino-acid d-serine. The efficiency of this approach is derived from the use of principles of memory of chirality and dynamic kinetic resolution in the intramolecular aldol reaction of a serine derivative to build the densely functionalized lactam framework and to install three contiguous stereocenters. The key intermediate was readily elaborated to the target natural product.

The facile production of N-methyl amino acids via oxazolidinones

Aurelio, Luigi,Brownlee, Robert T. C.,Hughes, Andrew B.,Sleebs, Brad E.

, p. 425 - 433 (2007/10/03)

A range of oxazolidinones derived from N-carbamoyl α-amino acids were prepared by an efficient method as key intermediates in the synthesis of N-methyl amino acids and peptides. The method was readily applied to most α-amino acids except those with basic side chains. The oxazolidinones were converted by reductive cleavage into N-methyl α-amino acids. CSIRO 2000.

(Phosphinyloxy)acid amino acid inhibitors of angiotensin converting enzyme. 2. Terminal amino acid analogues of (S)-1-[6-Amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]- L-proline

Karanewsky,Badia,Cushman,DeForrest,Dejneka,Lee,Loots,Petrillo

, p. 1459 - 1469 (2007/10/02)

Analogues of (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]- L-proline (1, SQ 29,852) in which the terminal proline residue has been replaced by a variety of substituted and heteroatom-substituted prolines, N-arylglycines, N-cycloalkylglycines, and bicyclic amino acids have been synthesized and evaluated as inhibitors of angiotensin converting enzyme in vitro an in vivo. In general, the addition of lipophilic substituents to the 4-position of proline of the parent phosphate 1 resulted in substantial increases in vitro activity. The largest improvements were observed in the case of cis-benzyl (36-fold) and dithioketal (24-fold) analogues 2r and 2x, respectively. These enhancements of in vitro activity were accompanied by modest increases (2-3.5-fold) in in vivo (iv) activity. Among the various terminal amino acid replacements examined in this study, the indoline-based analogue 2i was by far the most potent compound on iv administration in the normotensive rat.

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