97546-23-1Relevant academic research and scientific papers
Synthesis of new lipophilic acyclic di-ionizable polyethers, bis(crown ethers) and macrocyclic diamides
Elshani, Sadik,Wai, Chien M.,Natale,Bartsch, Richard A.
, p. 9425 - 9438 (2007/10/03)
A series of new lipophilic acyclic polyethers containing two carboxylic or hydroxamic acid groups have been prepared. From lipophilic acyclic polyether dicarboxylic acids 2, 9 and 13, the bis(crown ethers) 20-25 were synthesized. From lipophilic acyclic polyether dicarboxylic acids 10-12 and 14, the new macrocyclic diamides 26-32 were prepared in high yields without the use of high dilution techniques or template effects.
Calcium ionophores as cardiac stimulants. I. Diacids derived from dibenzo crown ethers
Ball,Cooper,Main
, p. 137 - 143 (2007/10/02)
A series of calcium chelating agents has been prepared based on carboxylic derivatives of open chain 18-Crown-6 analogues. Most of these are efficient calcium binding agents, many form lipophilic calcium complexes, and some of these are capable of releasing Ca2+ from liposomes by ionophore action. The best of these is 1,2-bis-[2-(1-carboxydecyloxy)phenoxy]ethane. This compound is cardiotonic in vitro but in the dog vasoconstriction it is the predominant biological effect.
