97579-25-4

Upstream product

• 7357-70-2 Cyanothioacetamide 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 131270-65-0 2-Cyano-3-(4-fluoro-phenyl)-3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-thiopropionamide; compound with morpholine 
• 105648-21-3 2,4,4-Tricyano-3-(4-fluoro-phenyl)-but-3-enethioic acid amide 
• 1388115-09-0 N-methylmorpholinium-(4R/4S)-3-cyano-4-(4-fluorophenyl)6-oxo-1,4,5,6-tetrahydropyridine-2-thiolate 
• 1220247-88-0 C₂₉H₂₂FN₅O₂S 
• 1220247-75-5 C₂₁H₁₆FN₃O₂S 
• 1220247-90-4 C₂₈H₁₈FN₅O₃S 
• 1220247-89-1 C₂₈H₁₉FN₄OS 
• 1220247-84-6 C₂₀H₁₃FN₄S 

Relevant academic research and scientific papers

Design and synthesis of pyrido[2,1- b ][1,3,5]thiadiazine library via uncatalyzed mannich-type reaction

This Research Article describes the synthesis of an over 700-member library of (8R/8S)-3-R-8-aryl-6-oxo-3,4,7,8-tetrahydro-2H,6H-pyrido[2,1-b][1,3,5]thiadiazin-9-carbonitriles by uncatalyzed Mannich-type reaction of N-methylmorpholinium (4R/4S)-4-aryl-3-cyano-6-oxo-1,4,5,6-tetrahydropyridin-2-thiolates with a set of primary amines and excessive HCHO. The scope and limitations of the reaction were studied. Starting thiolates were obtained in yields of 53-82% by multicomponent reaction of aromatic aldehydes, cyanothioacetamide, 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum's acid), and N-methylmorpholine, followed by heterocyclization of the resulting Michael adducts.