97579-98-1

Upstream product

• 5959-36-4 ethyl 4-aminobutyrate 
• 1885-14-9 phenyl chloroformate 
• 97579-94-7 3-(N-allyl-N-phenoxycarbonylamino)-1-ethoxycarbonyl-1-iodopropane 
• 97579-90-3 4-(Allyl-phenoxycarbonyl-amino)-2-bromo-butyric acid ethyl ester 
• 97579-86-7 3-(N-allyl-N-phenoxycarbonylamino)-1-ethoxycarbonylpropane 
• 6937-16-2 ethyl γ-aminobutyrate hydrochloride 

Downstream Products

• 97603-06-0 1-ethoxycarbonyl-4-phenoxycarbonyl-4-azabicyclo<4,1,0>heptane 

Relevant academic research and scientific papers

Evidence that Palladium(0)-Promoted Cyclizations of Unsaturated α-Iodocarbonyls Occur by an Atom Transfer Mechanism

The isomerization of several unsaturated α-iodocarbonyls to cyclic γ-iodocarbonyls gave identical product mixtures by using catalytic quantities of either hexalkylditin or palladium(0).This indicates that palladium does not serve as a catalyst in an organometallic reaction, but as a promotor of a free radical chain involving atom transfer.In contrast, an allylic iodide showed no tendency to produce radical chain products when treated with Pd(0).

PALLADIUM CATALYZED ENE-HALOGENOCYCLIZATION OF α-HALOESTER HAVING INTERNAL DOUBLE BOND WITH THE LOW-VALENT METAL COMPLEX

α-Haloester having internal double bond was reacted with a catalytic amount of Pd(Ph3)4 to afford the cyclized product in good yield and the same product was obtained by treatment of ketene silyl acetal with divalent palladium complex.

REACTION OF α-HALOESTER HAVING INTERNAL DOUBLE BOND WITH THE LOW-VALENT METAL COMPLEX

The α-haloester having an internal double bond was allowed to react with a catalytic amount of Pd(PPh3)4 to afford a cyclized product in a fairly good yield and the same product was obtained by treatment with Pd(OAc)2 to ketene silyl acetal.