97595-21-6

Upstream product

• 696-62-8 para-iodoanisole 
• 15982-64-6 1,4-bis(4-methoxyphenyl)butane-1,4-dione 
• 6165-68-0 thiophene boronic acid 
• 106-41-2 4-bromo-phenol 
• 5720-07-0 4-methoxyphenylboronic acid 
• 133752-62-2 C₁₁H₉ClOSZn 
• 55827-09-3 2,5-bis(4-methoxyphenyl)thiophene 
• 874525-31-2 1,2-dibromo-1,2-di(4-methoxybenzoyl)ethane 

Downstream Products

• 1449674-28-5 C₂₄H₂₀O₄S 
• 133730-75-3 2,5-bis(4-oxo-2,5-cyclohexadien-1-ylidene)-2,5-dihydrothiophene 

Relevant academic research and scientific papers

A porphyrin porous organic polymer with bicatalytic sites for highly efficient one-pot tandem catalysis

A novel porphyrin-based porous organic polymer PPOP-1(Pd) with bifunctional catalytic sites was constructed via imine condensation of tetra(4-aminophenyl)porphyrin and acenaphthenequinone. PPOP-1(Pd) containing Pd(ii)-porphyrin and Pd(ii)-α-diimine moieties exhibits excellent catalytic activity and outstanding reusability for tandem catalytic reactions of C-H arylation and Suzuki coupling.

Reversible light-directed self-organized 3D liquid crystalline photonic nanostructures doped with azobenzene-functionalized bent-shaped molecules

Blue phases in self-assembled 3D periodic nanostructures endowed with sensitive photoresponsive capability were prepared by doping bent-core molecules with photochromic azobenzene moieties. The molecular configurations are found to be critical to the stab

The effects of asymmetric bent-shaped compounds on the temperature range and electro-optical performances of liquid crystalline blue phases

A series of asymmetric and symmetric bent-shaped molecules with branched terminals were synthesized and characterized. Their effects on inducing blue phase and electro-optical performances were compared and analyzed experimentally. It was found that the asymmetric and symmetric compounds almost have the same effect on inducing and stabilizing blue phase, but the electro-optical performance of mixtures doped with asymmetric compounds are much better than that of mixtures doped with symmetric compounds for they have a totally different dielectric anisotropy which can contribute to a larger Kerr constant.

Polymerizable mesogen compound having improved photoreactive efficiency and polymerizable liquid crystal compositions containing the same

The present invention relates to a polymerizable mesogen compound having improved photo-reaction efficiency by introducing an alpha-thiomethyl acrylate group as a photo-reactive group, and to a polymerizable liquid crystal composition containing the same. The polymerizable mesogen compound of the present invention has improved photo-reaction efficiency at a relatively low energy state by introducing an alpha-thiomethyl acrylate group as a photo-reactive group, retains excellent solubility in a host liquid crystal due to an asymmetric structure thereof, and improves stability of the pretilt angle after photo-crosslinking, and thus can be useful as a polymerizable liquid crystal composition, particularly, a polymerizable liquid crystal composition for a polymer stabilization alignment type liquid crystal display.

Thiophene-core estrogen receptor ligands having superagonist activity

To probe the importance of the heterocyclic core of estrogen receptor (ER) ligands, we prepared a series of thiophene-core ligands by Suzuki cross-coupling of aryl boronic acids with bromo-thiophenes and we assessed their receptor binding and cell biological activities. The disposition of the phenol substituents on the thiophene core, at alternate or adjacent sites, and the nature of substituents on these phenols, all contribute to binding affinity and subtype selectivity. Most of the bis(hydroxyphenyl)-thiophenes were ERβ selective, whereas the tris(hydroxyphenyl)-thiophenes were ERα selective; analogous furan-core compounds generally have lower affinity and less selectivity. Some diarylthiophenes show distinct superagonist activity in reporter gene assays, giving maximal activities 2-3 times that of estradiol, and modeling suggests that these ligands have a different interaction with a hydrogen-bonding residue in helix-11. Ligand-core modification may be a new strategy for developing ER ligands whose selectivity is based on having transcriptional activity greater than that of estradiol.

REACTIVE MESOGEN COMPOUND, LIQUID CRYSTAL COMPOSITION INCLUDING THE SAME, METHOD OF MANUFACTURING A DISPLAY PANEL, AND DISPLAY PANEL

A reactive mesogen compound, a liquid crystal composition including the reactive mesogen compound, a method of manufacturing a display panel, and a display panel are disclosed. The reactive mesogen compound may be activated by light having a wavelength be

Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1)

17β-Estradiol (E2), the most potent female sex hormone, stimulates the growth of mammary tumors and endometriosis via activation of the estrogen receptor α (ERα). 17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1), which is responsible for the catalytic r

Design, synthesis, and structure-activity relationship of novel thiophene derivatives for β-amyloid plaque imaging

Novel 2,5-diphenylthiophene derivatives were synthesized and structure activity relationship with regard to Aβ plaque binding was studied. Binding affinities of these compounds were found to range from 3.9 to >1000 nM, depending on the substitution patter

Nematic 2,5-disubstituted thiophenes

A large number of new liquid crystals incorporating the 2,5-disubstituted thiophene ring have been prepared and their mesomorphic behaviour studied in order to systematically investigate the correlation between the molecular structure and mesomorphism of thiophene derivatives with different shapes, polarisability and polarity. As a consequence of these investigations we have prepared a new class of liquid crystals incorporating a 2,5-disubstituted thiophene ring and a conjugated trans-carbon-carbon double bond in the terminal chain. These novel thiophene derivatives are the first liquid crystals incorporating a 2,5-disubstituted thiophene ring to exhibit a nematic phase at room temperature. This enables the flexoelectric coefficients of a bent-shaped molecule to be measured directly and at room temperature for the first time to the authors' knowledge. Many of these new thiophenes exhibit a high birefringence and a high nematic clearing point and are of potential use as components of nematic mixtures in LCDs.

Electronic and magnetic metal-metal interactions in dinuclear oxomolybdenum(V) complexes across bis-phenolate bridging ligands with different spacers between the phenolate termini: Ligand-centred vs. metal-centred redox activity

A series of dinuclear complexes has been prepared in which two {MoV(TpMe,Me)(O)Cl} fragments (abbreviated as Mo; TpMe,Me = tris(3,5-dimethylpyrazol-1-yl)hydroborate) are attached to either end of a bis-p-phenolate bridging ligand [(4,4′-OC6 H4)-X-(4,4′-C6H4O)]2-. The complexes are Mo2 (C=C)(X = CH=CH), Mo2(C=C)2 (X = CH=CH-CH=CH), Mo2(C=C)3 (X = CH=CH-CH=CH-CH=CH), Mo2(th) (X = 2,5-thiophenediyl), Mo2(th)2 (X = 2,5:2′,5′-bithiophenediyl), Mo2(th)3 (X = 2,5:2′,5′:2″,5″-terthiophenediyl), Mo2 (C≡C) (X = C≡C), Mo2(N=N) (X = N=N), Mo2(CO) [X = C(O)] and Mo2(C2ΦC2) [X = CH=CH(1,4-C6H4)CH=CH]. Electrochemical, UV/VIS/NIR spectroelectrochemical and magnetic measurements have been carried out in order to see how effectively the different spacer groups X mediate electronic and magnetic interactions between the two redox-active, paramagnetic, Mo centres. The electronic interactions were determined from the redox separation between the two successive one-electron oxidations which are formally Mo(VI)-Mo(V) couples; it was found that thienyl units in the bridging ligand are much more effective at maintaining electronic communication over long distances than p-phenylene or ethenyl spacers of comparable lengths. The azo (N=N) linkage afforded a much weaker electronic interaction than the ethenyl or ethynyl spacers. UV/VIS/NIR spectroelectrochemical studies showed that whereas the first oxidation is metal-centred to give Mo(VI)-Mo(V) species with characteristic intense phenolate→Mo(VI) LMCT transitions in the near-IR region, the spectra of the doubly oxidised complexes are characteristic of quinones: thus, the sequence of species formed on oxidation is [Mo(V)(μ-diolate)Mo(V)]0→[Mo(V)(μ-diolate)Mo(VI)] +→[Mo(V)(μ-quinone)Mo(V)]+2, with an internal charge redistribution associated with the second oxidation. Semi-empirical ZINDO calculations provide some support for this. Magnetic susceptibility measurements on Mo2(C=C), Mo2(th), Mo2(N=N) and Mo2(C≡C) show that all are weakly antiferromagnetically coupled, as expected on the basis of a spin-polarisation picture, with the order of strength of the magnetic interaction being the reverse of the order for electronic coupling, such that Mo2(th) affords the strongest electronic interaction but the weakest magnetic interaction.