97602-72-7

Usage

Structure

1H-Imidazole-4-carboxylic acid derivative with a methyl ester group and a methyl group attached to the second carbon of the imidazole ring.

Type of compound

A chemical compound and a valuable reagent.

Common uses

Synthesis of pharmaceuticals, organic chemistry reactions, drug discovery and development, and preparation of various bioactive compounds.

Fields of application

Medicine, research, and scientific study.

Upstream product

• 67-56-1 methanol 
• 1457-58-5 2-methyl-1H-imidazole-4-carboxylic acid 
• 118493-85-9 acetamide oxime 
• 922-67-8 propynoic acid methyl ester 
• 97602-58-9 methyl (E)-3-(5-methyltetrazol-1-yl)propenoate 

Downstream Products

• 131077-90-2 Methyl 1-(2,4-dibromophenyl)-2-methylimidazole-4-carboxylate 

Relevant academic research and scientific papers

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

Triazine Derivatives

The present invention is directed to a new class of triazine derivatives as described by formula I below in which A, X, R1, R2, R3, and R4 are as defined herein and to the use of the compounds as PDE10 inhibitors.

Two-step Synthesis of Imidazoles from Activated Alkynes

Conjugate addition of 2-(tri-n-butylstannyl)tetrazoles (1) to activated alkynes gives 1-alkenyltetrazoles (4) and (5) predominantly.Use of the N-tributylstannyl derivatives, rather than the parent tetrazole, gives a high ratio of 1- to 2-alkenyl isomers and avoids the complication of further addition of the tetrazole or the alkyne to the initial adduct.Irradiation of the (Z)- and (E)-1-alkenyltetrazoles (4) and (5) at 254 nm then gives the expected imidazoles in moderate yield.However, 5-phenyl-2-(tri-n-butylstannyl)tetrazole (1a) reacted only slowly with ethyl phenylpropiolate to give ethyl 3,5-diphenylpyrazole-4-carboxylate (8), presumably via the 2-alkenyltetrazole (9) formed in preference to the 1-isomer for steric reasons.