97606-26-3Relevant academic research and scientific papers
One small molecule as a theranostic agent: Naphthalimide dye for subcellular fluorescence localization and photodynamic therapy: In vivo
Zhang, Lei,Lei, Kecheng,Zhang, Jingwen,Song, Wenlin,Zheng, Yuanhong,Tan, Shaoying,Gao, Yuwei,Xu, Yufang,Liu, Jianwen,Qian, Xuhong
supporting information, p. 1171 - 1175 (2016/07/06)
A novel single and small molecular theranostic agent (1a) based on a naphthalimide dye has been developed and characterized. The agent (1a) displays excellent fluorescence for cell imaging (fluorescent quantum yields of 0.81) and photodynamic effects for
Naphthalimide intercalators with chiral amino side chains: Effects of chirality on DNA binding, photodamage and antitumor cytotoxicity
Yang, Qing,Yang, Peng,Qian, Xuhong,Tong, Lianpeng
scheme or table, p. 6210 - 6213 (2009/07/18)
Several novel heterocyclic-fused naphthalimides intercalators with chiral amino side chains were investigated. Their side chains' chiral configuration determines DNA binding activities in the order: S-enantiomers > R-enantiomers. And their DNA photodamagi
Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains: Intercalation and photocleavage to DNA
Xu, Yufang,Qu, Baoyuan,Qian, Xuhong,Li, Yonggang
, p. 1139 - 1142 (2007/10/03)
Novel five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains were designed, synthesized and evaluated. These compounds have high Scatchard binding constants. They could damage DNA (supercoiled pBR322) from form I (closed) to II (ni
Synthesis, antitumor and DNA photocleaving activities of novel naphthalene carboxamides: Effects of different thio-heterocyclic rings and aminoalkyl side chains
Li, Zhigang,Yang, Qing,Qian, Xuhong
, p. 8711 - 8717 (2007/10/03)
Two kinds of thio-heterocyclic fused naphthalene carboxamides, 3a-b, 4a-b, were designed, synthesized and quantitatively evaluated as efficient antitumor and DNA photocleaving agents. Compound 3a or 3b, having the thiophene ring, intercalated into DNA mor
Novel naphthalimide hydroperoxide photonucleases: The role of thiocyclic-Fused area and the difference in spectra, photochemistry and photobiological activity
Xu, Yufang,Qian, Xuhong,Yao, Wei,Mao, Ping,Cui, Jingnan
, p. 5427 - 5433 (2007/10/03)
Novel five- and six-membered thiocyclic-fused naphthalimide hydroperoxides (7, 8) as photonucleases were designed, synthesized via unusual isomerization in Pschorr cyclization and photooxygenation. The five-membered 7 was able to induce single-strand nick
Novel and highly efficient DNA photocleavers: Hydroperoxides of heterocyclic-fused naphthalimides
Yao, Wei,Qia, Xuhong,Hu, Qingyan
, p. 7711 - 7715 (2007/10/03)
A series of novel hydroperoxides of heterocyclic-fused naphthalimides were designed, synthesized and exhibited excellent DNA photonicking activities. Among these compounds, the benzothiophenonaphthalimide-type reagent proved to be the most efficient, it c
