97608-49-6

Basic information

• Product Name: 2,6-Dichelorotrifluoromethoxybenzene
• Synonyms: 2,6-Dichelorotrifluoromethoxybenzene;1,3-dichloro-2-(trifluoromethoxy)benzene;2,6-Dichlorophenyl trifluoromethyl ether;1,3-Dichloro-2-(trifluoromethoxy);2,6-dichloro-1-(trifluoromethoxy)benzen
• CAS NO: 97608-49-6
• Molecular Formula: C₇H₃Cl₂F₃O
• Molecular Weight: 230.9993296
• Mol File: 97608-49-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,6-Dichelorotrifluoromethoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichelorotrifluoromethoxybenzene(97608-49-6)
• EPA Substance Registry System: 2,6-Dichelorotrifluoromethoxybenzene(97608-49-6)

Safety Data

• Hazardous Substances Data: 97608-49-6(Hazardous Substances Data)

Usage

Uses

1,3-Dichloro-2-(trifluoromethoxy)benzene is a useful synthetic intermediate in the synthesis of 4-Chloro-3-(trifluoromethoxy)aniline (C421915); a reagent in the preparation of diazepanone compounds as chemokine receptor antagonists for the treatment of inflammatory diseases.

InChI:InChI=1S/C7H3Cl2F3O/c8-4-2-1-3-5(9)6(4)13-7(10,11)12/h1-3H

Upstream product

• 541-73-1 1,3-Dichlorobenzene 
• 1984-65-2 2,6-dichloroanisole 
• 87-65-0 2,6-Dichlorophenol 
• 97608-48-5 1,3-Dichloro-2-trichloromethoxy-benzene 

Downstream Products

• 97608-50-9 4-chloro-3-(trifluoromethoxy) aniline 
• 1437779-74-2 2-(3,5-dichloro-4-(trifluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1437779-75-3 1,3-dichloro-2-(trifluoromethoxy)-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene 
• 1437779-34-4 5-(5-(3,5-Dichloro-4-(trifluoromethoxy)phenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol 

Relevant articles and documents

DIFLUOROMETHOXYLATION AND TRIFLUOROMETHOXYLATION COMPOSITIONS AND METHODS FOR SYNTHESIZING SAME

The present invention provides a compound having the structure (I), a processing of making the compound; and a process of using the compound as a reagent for the difluoromethoxylation and trifluoromethoxylation of arenes or heteroarenes.

A safe and economical synthesis of 3-(trifluoromethoxy) aniline from 2-chlorophenol

A simple, safe and realistic synthesis of 3-(trifluoromethoxy) aniline from 2-chlorophenol is proposed, the key step being a regiospecific arynic amination of 2-chloro (trifluoromethoxy) benzene.This method has been extended to the synthesis of 4-chloro-3-(trifluoromethoxy) aniline from 2,6-dichlorophenol.Some unusual products are obtained during the reaction between sodium amide and 2-chloro (chlorodifluoromethoxy) benzene, the formation of which is discussed.