97621-10-8

Upstream product

• 14062-21-6 (4-isopropylphenyl)acetic acid ethyl ester 
• 95-92-1 oxalic acid diethyl ester 
• 623-49-4 ethyl cyanoformate 
• 4476-28-2 (4-isopropylphenyl)acetic acid 
• 99-87-6 4-methylisopropylbenzene 
• 2051-18-5 4-isopropylbenzyl chloride 
• 19213-72-0 ethyl 1-imidazolecarboxylate 
• 4395-87-3 (4-isopropylphenyl)acetonitrile 

Downstream Products

• 926008-55-1 5-(4-isopropylphenyl)pyrimidine-4,6-diol 
• 926008-75-5 {4-[6-chloro-5-(4-isopropylphenyl)pyrimidin-4-ylethynyl]phenyl}dimethylamine 
• 146533-34-8 4,6-dichloro-5-(4-isopropyl-phenyl)-pyrimidine 

Relevant academic research and scientific papers

An efficient method for the preparation of mono α-aryl derivatives of diethyl malonate and ethyl cyanoacetate using ethyl-1-imidazole carbamate (EImC)

An efficient method for the synthesis of mono α-aryl derivatives of diethyl malonate and ethyl cyanoacetate using ethyl-1-imidazole carbamate (EImC) has been described. Using this method many sterically hindered and highly substituted mono α-aryl derivatives of diethyl malonate and ethyl cyanoacetate were synthesized in high yield.

4-Amino-5-aryl-6-arylethynylpyrimidines: Structure-activity relationships of non-nucleoside adenosine kinase inhibitors

A series of non-nucleoside adenosine kinase (AK) inhibitors is reported. These inhibitors originated from the modification of 5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine (ABT-702). The identification of a linker that would approximate the spatial arrangement found between the pyrimidine ring and the aryl group at C(7) in ABT-702 was a key element in this modification. A search of potential linkers led to the discovery of an acetylene moiety as a suitable scaffold. It was hypothesized that the aryl acetylenes, ABT-702, and adenosine bound to the active site of AK (closed form) in a similar manner with respect to the orientation of the heterocyclic base. Although potent acetylene analogs were discovered based on this assumption, an X-ray crystal structure of 5-(4-dimethylaminophenyl)-6-(6-morpholin-4-ylpyridin-3-ylethynyl)pyrimidin-4-ylamine (16a) revealed a binding orientation contrary to adenosine. In addition, this compound bound tightly to a unique open conformation of AK. The structure-activity relationships and unique ligand orientation and protein conformation are discussed.