97651-27-9

Upstream product

• 93440-31-4 α-thiocarbamoyl-β-(4'-nitrophenyl)acrylonitrile 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 148119-03-3 5-Cyano-6-ethylsulfanyl-2-methyl-4-(4-nitro-phenyl)-nicotinic acid ethyl ester 
• 148119-07-7 3-Amino-6-methyl-4-(4-nitro-phenyl)-thieno[2,3-b]pyridine-2,5-dicarboxylic acid 5-ethyl ester 2-methyl ester 
• 148119-15-7 2-Acetyl-3-imino-6-methyl-4-(4-nitro-phenyl)-2,3-dihydro-thieno[2,3-b]pyridine-2,5-dicarboxylic acid diethyl ester 

Relevant academic research and scientific papers

REACTIONS WITH CYANOTHIOACETAMIDE DERIVATIVES: SYNTHESIS AND REACTIONS OF SOME PYRAZOLOPYRIDINE DERIVATIVES

The ylidene derivatives of cyanothioacetamide 1a-d reacted with ethyl acetoacetate to give the pyridinethiol derivatives 2a-d.Compounds 2a-d were used as starting material for the synthesis of several heterocyclic compounds.Reaction with hydrazine hydrate, ethyl iodide, methyl chloroacetate and α-chloro ethyl acetoacetate gave the pyridine and annelated pyridine derivatives 5a-d, 6a-d, 7a, 8b-d, and 12a-d, respectively.Compounds 7a, 8b-d and 12a-d reacted with hydrazine hydrate to yield the annelated pyridines 10a-d and 15a-d, respectively.Key words: Cyanothioacetamide; pyridines; thienopyridines; pyrazolopyridines; thienospiropyrazolopyridines.

SYNTHESIS OF 3-CYANO-4-ARYL-5-ETHOXYCARBONYL-6-METHYL-3,4-DIHYDROPYRIDINE-2-THIONES

The condensation of ethyl arylideneacetoacetate with cyanothioacetamide and of arylidenecyanothioacetamides with ethyl acetoacetate or of arylidenecyanothioacetamides with ethyl β-aminocrotonate gave 3-cyano-4-aryl-5-ethoxycarbonyl-6-methyl-3,4-dihydropyridine-2-thiones.PMR spectroscopy showed that the 3-cyano-4-aryl-3,4-dihydropyridine-2-thiones are formed as a mixture of cis and trans isomers.