93440-31-4

Usage

Physical state

Yellow to orange solid

Primary use

Intermediate for production of other chemicals

Natural occurrence

Not commonly found in nature

Production method

Typically produced synthetically

Potential applications

Pharmaceutical research and development

Need for further research

To determine potential uses and properties

Upstream product

• 73610-36-3 6-amino-3,5-dicyano-2,4-bis-(4-nitro-phenyl)-3,4-dihydro-2H-thiopyran-3-carbothioic acid amide 
• 7357-70-2 Cyanothioacetamide 
• 555-16-8 4-nitrobenzaldehdye 
• 2700-23-4 4-Nitrobenzylidenemalononitrile 
• 19172-47-5 Lawessons reagent 
• 3237-22-7 2-cyano-3-(2-furanyl)acrylonitrile 

Downstream Products

• 131270-74-1 2-Cyano-3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-3-(4-nitro-phenyl)-thiopropionamide; compound with morpholine 
• 97651-27-9 5-Cyano-6-mercapto-2-methyl-4-(4-nitro-phenyl)-nicotinic acid ethyl ester 
• 117601-24-8 4-(4-nitrophenyl)-2-thioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 252001-57-3 6-methyl-5-acetyl-4-(4-nitrophenyl)-3-cyano-3,4-dihydropyridine-2-thione 
• 264195-71-3 2-hydrazino-7-(4-nitro-phenyl)-5-oxo-5H-pyrano[2,3-d]thiazole-6-carbothioic acid amide 
• 131270-84-3 2-Mercapto-7,7-dimethyl-4-(4-nitro-phenyl)-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile; compound with morpholine 
• 264195-73-5 2-hydrazino-7-(4-nitro-phenyl)-6-(4-oxo-4,5-dihydro-thiazol-2-yl)-pyrano[2,3-d]thiazol-5-one 
• 264195-90-6 8-(p-Nitrophenyl)-3,6-dioxo-7-thiocarboxamidopyrano[2',3':4,5]thiazolo[2,3-c]-1,2,4-triazole 
• 264195-98-4 2-(3,5-dimethyl-pyrazol-1-yl)-7-(4-nitro-phenyl)-5-oxo-5H-pyrano[2,3-d]thiazole-6-carbothioic acid amide 
• 264195-94-0 8-(4-nitro-phenyl)-3,4,6-trioxo-3,4-dihydro-2H,6H-5-oxa-9-thia-1,2,4a-triaza-fluorene-7-carbothioic acid amide 
• 264195-79-1 2-[N'-(4-nitro-benzylidene)-hydrazino]-7-(4-nitro-phenyl)-5-oxo-5H-pyrano[2,3-d]thiazole-6-carbothioic acid amide 
• 264195-82-6 3,7-bis-(4-nitro-phenyl)-5-oxo-5H-4-oxa-8-thia-1,2,3a-triaza-cyclopenta[a]indene-6-carbothioic acid amide 
• 264195-88-2 7-(4-Nitro-phenyl)-2-{N'-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazino}-6-(4-oxo-4,5-dihydro-thiazol-2-yl)-pyrano[2,3-d]thiazol-5-one 
• 264195-86-0 3,7-bis-(4-nitro-phenyl)-6-(4-oxo-4,5-dihydro-thiazol-2-yl)-4-oxa-8-thia-1,2,3a-triaza-cyclopenta[a]inden-5-one 

Relevant academic research and scientific papers

Novel multicomponent synthesis of 6,7-dihydro-5H-cyclopenta[b]pyridine derivatives

[Figure not available: see fulltext.] The multicomponent condensation of malononitrile, hydrogen sulfide, aldehydes, 1-(cyclopent-1-en-1-yl)pyrrolidine, and alkylating agents leads to the formation of 6,7-dihydro-5H-cyclopenta[b]pyridine derivatives. The structure of a number of heterocycles obtained on their basis was studied by X-ray structural analysis.

Design and synthesis of pyrido[2,1- b ][1,3,5]thiadiazine library via uncatalyzed mannich-type reaction

This Research Article describes the synthesis of an over 700-member library of (8R/8S)-3-R-8-aryl-6-oxo-3,4,7,8-tetrahydro-2H,6H-pyrido[2,1-b][1,3,5]thiadiazin-9-carbonitriles by uncatalyzed Mannich-type reaction of N-methylmorpholinium (4R/4S)-4-aryl-3-cyano-6-oxo-1,4,5,6-tetrahydropyridin-2-thiolates with a set of primary amines and excessive HCHO. The scope and limitations of the reaction were studied. Starting thiolates were obtained in yields of 53-82% by multicomponent reaction of aromatic aldehydes, cyanothioacetamide, 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum's acid), and N-methylmorpholine, followed by heterocyclization of the resulting Michael adducts.

Organophosphorus chemistry, 291. The action of 2,4-bis-(4-methoxyphenyl)-1,3,2,4-dithiaphosphetane-2,4-disulfide (Lawesson's reagent) on α, ss-unsaturated nitriles

The reaction of 2,4-bis-(4-methoxyphenyl)-1,3,2,4-dithiaphosphetane-2,4-disulfide (Lawesson's reagent. LR, 1) with ylidenemalononitriles (5a-f) was studied. Partial hydrolysis of 5a-f followed by thiation with LR yields the respective thioamides 7a-f. Nuc

Condensation of α-cyanothioacetamide with aldehydes catalyzed by Envirocat EPZG

Condensation of α-cyanothioacetamide with aldehydes has been carried out in excellent yield under mild conditions by using Envirocat EPZG as a heterogenous reusable catalyst.

Substituent Effects on a Reversible Cycloaddition Reaction

The effect of substituents in the aryl group on the reversible dimerisation of 3-aryl-2-cyanothioacrylamides (a δ+4δ> cycloaddition) has been determined from measurement of the equilibrium constants by 1H n.m.r. spectroscopy.For a series of seven such compounds the free-energy change and enthalpy change show opposite linear correlation with the substituent Hammett ? values and these trends are rationalised in terms of the substituent perturbation to the frontier orbitals.The parameters ΔH0 and ΔS0 show a reverse correlation with ΔG0 and a direct correlation with each other.The isokinetic temperature has been evaluated.