97652-66-9

Upstream product

• 96125-49-4 methyl trans-3-(4-methoxyphenyl)glycidate 
• 88-75-5 2-hydroxynitrobenzene 
• 824-39-5 sodium o-nitrophenate 

Downstream Products

• 97652-69-2 trans-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzoxazepin-4(5H)-one 
• 97652-90-9 (2S,3S)-3-(2-Amino-phenoxy)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid 
• 97652-69-2 cis-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzoxazepin-4(5H)-one 
• 97652-90-9 (2R,3S)-3-(2-Amino-phenoxy)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid 
• 97652-72-7 cis-2,3-dihydro-5-<2-(dimethylamino)ethyl>-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzoxazepin-4(5H)-one 
• 97652-72-7 (6R,7R)-9-(2-Dimethylamino-ethyl)-7-hydroxy-6-(4-methoxy-phenyl)-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-one 
• 97652-73-8 (6R,7R)-9-(3-Dimethylamino-propyl)-7-hydroxy-6-(4-methoxy-phenyl)-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-one 
• 97652-73-8 (6R,7S)-9-(3-Dimethylamino-propyl)-7-hydroxy-6-(4-methoxy-phenyl)-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-one 
• 97652-68-1 methyl threo-3-(2-aminophenoxy)-2-hydroxy-3-(4-methoxyphenyl)propionate 
• 97652-68-1 methyl erythro-3-(2-aminophenoxy)-2-hydroxy-3-(4-methoxyphenyl)propionate 

Relevant academic research and scientific papers

Enantioselectivity of Pseudomonas cepacia lipase for the acetylation of 2-hydroxy carboxylic acid esters+

Structurally different ethyl or methyl 2-hydroxy carboxylates were resolved by Pseudomonas cepacia lipase-catalysed acetylations with vinyl acetate in diethylether. One type of the alcoholic substrates (2-hydroxy-2-arylacetates and 2-hydroxy-3-arylpropinates) contained a HO-group at the stereocentre. These compounds were resolved with high enantioselectivity (ee 91 → 99) at ca. 50% conversion. The other alcoholic substrates ((threo-2-hydroxy-3-methylbutyrate and threo- or erythro-2-hydroxy-3-aryl-3-arylthio(or aryloxy)propionates) with two stereocentres generally resulted in enantiopure products and the reactions stopped at 50 % conversion.

Reactions of 3-phenylglycidic esters. V. Reaction of methyl 3-(4-methoxyphenyl)glycidate with 2-nitroaniline and synthesis of 1,5-benzodiazepine derivatives

Stereochemical aspects of the oxirane-ring opening of methyl trans-3-(4-methoxyphenyl)-glycidate (1) with 2-nitroaniline (5) were investigated. ZnI2 showed good catalytic activity in this reaction, giving the cis-opening product (6a) predominan