97664-54-5Relevant articles and documents
Novel process for preparing salmeterol
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, (2008/06/13)
Accordingly, the present invention provides a process for the preparation of a compound of formula (I) or a single enantiomer thereof, or a salt or a solvate thereof, wherein W is a chiral auxiliary or hydrogen and P1 and P2 are each
A mild, enantioselective synthesis of (R)-salmeterol via sodium borohydride-calcium chloride asymmetric reduction of a phenacyl phenylglycinol derivative
Bream, Robert N.,Ley, Steven V.,McDermott, Benjamin,Procopiou, Panayiotis A.
, p. 2237 - 2242 (2007/10/03)
A short and efficient enantioselective route to (R)-salmeterol involving asymmetric reduction of a phenylglycinyl ketone derivative followed by reductive amination of the resulting amino alcohol and hydrogenolysis is described.