97699-39-3

Upstream product

• 937-20-2 p-chlorophenacyl chloride 
• 108-90-7 chlorobenzene 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 1418143-55-1 1-bromo-2-(4-chlorophenyl)-3-buten-2-ol 

Downstream Products

• 97699-60-0 2-(4-Chloro-phenyl)-2-(N-methyl-hydrazino)-but-3-en-1-ol 
• 97699-54-2 2-(4-Chloro-phenyl)-1-(N-methyl-hydrazino)-but-3-en-2-ol 
• 97699-59-7 2-(4-Chloro-phenyl)-2-hydrazino-but-3-en-1-ol 

Relevant academic research and scientific papers

Synthetic Strategy for Tetraphenyl-Substituted All-E-Carotenoids with Improved Molecular Properties

The synthetic method of tetraphenyl-substituted all-E-carotenes 1 with improved properties of antioxidant and molecular electronic conductance was developed through the formation of tetraphenyl-substituted all-E-apocarotenedial 4. The synthesis highlighted the preparation of novel subunits containing phenyl substituent(s) with E-configuration starting from the key (E)-4-chloro-2-phenylbut-2-enal (10), utilizing conjugation effect with formyl group or easy recrystallization of sulfone compounds. Sulfone-mediated coupling methods of Julia and modified Julia–Kocienski olefinations utilizing the subunits were demonstrated to produce tetraphenyl-substituted apocarotenedials 4. The major all-E-forms (73–85 % selectivity) were easily purified by SiO2 chromatography and trituration with Et2O due to the presence of the polar formyl groups. The olefination of all-E-apocarotenedials 4 and Wittig salt 5 provided all-E-9,9',13,13'-tetraphenylcarotenes 1.

Synthesis, psychotropic and antidysrhythmic activities of insaturated hydroxyhydrazines

The synthesis of a series of α-ethylenic hydrazinoalcohols via the ring cleavage of α-ethylenic epoxides by hydrazides was described. The competitive attack by the nucleophils at the less substituted carbon atom (compounds Y), or at the carbon atom-2 (compounds Z) were discussed. The psychotropic and antidysrhythmic activities of these compounds were evaluated.