97730-95-5Relevant academic research and scientific papers
An efficient synthesis of 4-hydroxy-1H-indole-2-carbonitrile and its conversion to DPI 201-106
Estep
, p. 507 - 514 (2007/10/02)
A three-step synthesis of 4-hydroxy-1H-indole-2-carbonitrile (3) from commercially available 1,5,6,7-tetrahydro-4H-indol-4-one (4) via cyanation and subsequent halogenation/dehydrohalogenation proceeds in 84% overall yield. The conversion of 3 into positive inotrope DPI 201-106 (1) is also described.
3-Aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them
-
, (2008/06/13)
The compounds of formula I STR1 where R 1, R 2 and R have various significances, and physiologically acceptable hydrolyzable derivatives thereof having the hydroxy group in the 2 position of the 3-aminopropoxy side chain in esterified form, are useful as
