97744-10-0

Upstream product

• 143656-03-5 N-benzyl-8-aza-4,10-dimethyl-decal-4-en-3-one 
• 34737-89-8 1-Benzyl-3-methyl-4-piperidon 
• 1629-58-9 4-penten-3-one 

Downstream Products

• 97744-02-0 N-benzyl-8-aza-4α,10-dimethyl-trans-decal-3β-ol 

Relevant academic research and scientific papers

INHIBITION OF Δ8-Δ7-STEROL ISOMERASE AND OF CYCLOEUCALENOL-OBTUSIFOLIOL ISOMERASE BY N-BENZYL-8-AZA-4α,10-DIMETHYL-TRANS-DECAL-3β-OL, AN ANALOGUE OF A CARBOCATIONIC HIGH ENERGY INTERMEDIATE

Key Word Index - Rubus fruticosus; Rosaceae; Zea mays; Gramineae; N-benzyl-8-aza-4α,10-dimethyl-trans-decal-3β-ol; high energy intermediate analogues; inhibition of Δ8 -> Δ7-sterol isomerase and of cycloeucalenol-obtusifoliol isomerase. - An enzymatic assay for the Δ8 -> Δ7-sterol isomerase, an enzyme involved in sterol biosynthesis, has been developed in higher plants.This assay has been used in the study of various inhibitors.N-Benzyl-8-aza-4α,10-dimethyl-trans-decal-3β-ol was designed to mimic the C-8 and C-9 carbocationic high energyintermediates occuring during the reactions catalysed by the Δ8 -> Δ7-sterol isomerase and the cycloeucalenol obtusifoliol isomerase, respectively.In accordance with the 'transition state analogues' theory, this analogue of a high energy intermediate was found to be a very potent and specific inhibitor of the two enzymatic reactions both in vitro and in vivo.