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Usage

Uses

Used in Biochemical Research:
2'-Azido-2'-deoxy-5-methyluridine is used as a research tool for studying the structure and interactions of RNA and DNA due to its ability to mimic natural nucleosides while introducing unique chemical handles for manipulation and analysis.
Used in the Synthesis of Nucleic Acid Analogs:
It serves as a precursor in the synthesis of other nucleoside analogs, which are essential for developing new therapeutic agents and understanding the fundamental processes of nucleic acid metabolism.
Used in Antiviral Drug Development:
2'-Azido-2'-deoxy-5-methyluridine is utilized in the development of antiviral drugs, where its unique chemical properties can be leveraged to inhibit viral replication or integrate into viral genomes, thereby disrupting their function.
Used in Click Chemistry Applications:
The azido group in 2'-Azido-2'-deoxy-5-methyluridine makes it a valuable compound in click chemistry, a field that employs selective chemical reactions to bind molecules together. This property is particularly useful in the creation of complex molecular structures and the development of targeted drug delivery systems.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2'-Azido-2'-deoxy-5-methyluridine is used as a key intermediate in the synthesis of novel nucleoside-based drugs, contributing to the advancement of treatments for various diseases, including viral infections and genetic disorders.

Upstream product

• 22423-26-3 O-2,2'-cyclo-5-methyluridine 

Relevant academic research and scientific papers

2′-Deoxy-2′-azidonucleoside analogs: synthesis and evaluation of antitumor and antimicrobial activity

Abstract: A series of ten pyrimidine nucleosides modified in 2′ position with azide or amine group was tested for the antibacterial, antifungal and cytotoxic activity. The cytotoxic effect was determined on three cancer (CCRF-CEM, MCF7, HeLa) and one norm

Cu(I)-catalyzed efficient synthesis of 2'-triazolo-nucleoside conjugates

A small library of thirty-two 2'-triazolyl uridine and 2'-triazolyl-5-methyluridine has been synthesized by Cu(I)-catalyzed condensation of 2'-azido-2'-deoxyuridine and 2'-azido-2'-deoxy-5-methyluridine with different alkynes and aryl propargyl ethers in almost quantitative yields. Triazolo-nucleoside conjugates, which can be evaluated for different biological activity for suitable drug development, were unambiguously identified on the basis of 1H NMR, 13C NMR, IR, and HRMS data analysis. These compounds have been synthesized for the first time and have not been reported in the literature earlier.

Synthesis and evaluation of thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

A number of 2′- and 3′-modified thymidine 5′-O-monophosphate analogues were synthesized as potential leads for new anti-mycobacterial drugs. Evaluation of their affinity for Mycobacterium tuberculosis thymidine monophosphate kinase showed that a 2′-halogeno substituent and a 3′-azido function are the most favorable leads for further development of potent inhibitors of this enzyme.