97771-05-6Relevant academic research and scientific papers
Sulfamic acid catalyzed direct condensation of aldehydes, amines, and TMSCN to α-aminonitriles at ambient temperature
Li, Zhenjiang,Sun, Yingjie,Ren, Xinghua,Wei, Ping,Shi, Yuhu,Ouyang, Pingkai
, p. 803 - 805 (2007/12/25)
A simple and efficient method has been developed for the synthesis of α-aminonitriles by a one-pot three-component condensation of aldehydes, amines, and trimethylsilyl cyanide in the presence of a catalytic amount of sulfamic acid at room temperature. Georg Thieme Verlag Stuttgart.
Indium trichloride catalyzed one-step synthesis of α-amino nitriles by a three-component condensation of carbonyl compounds, amines and potassium cyanide
Ranu, Brindaban C,Dey, Suvendu S,Hajra, Alakananda
, p. 2529 - 2532 (2007/10/03)
A simple and general method has been developed for the synthesis of α-aminonitriles by a one-pot three-component condensation of aldehydes or ketones, amines and potassium cyanide in THF in presence of a catalytic amount of indium trichloride.
A facile synthesis of substituted phenylglycines
Davies, Antony J.,Ashwood, Michael S.,Cottrell, Ian F.
, p. 1095 - 1102 (2007/10/03)
A convenient scaleable process for the preparation of substituted phenylglycines 2 by a modified Strecker reaction is described. Bisulfite- mediated addition of benzylamine and cyanide anion to substituted benzaldehydes 3 gave the aminonitriles 4 which were hydrolysed in two steps to the N-protected amino acid 1. Debenzylation using catalytic transfer hydrogenation gave the title compounds in good yield.
A Facile and High-Yield Synthesis of α-Benzylaminonitriles by A Modified Strecker Reaction
Georgiadis, Minas P.,Haroutounian, Serkos A.
, p. 616 - 618 (2007/10/02)
Several α-benzylaminonitriles have been synthesized in high yields by a one-pot reaction of carbonyl compounds with benzylamine, potassium cyanide, and acetic acid in methanol at 60 deg C for 20 hours.
