97818-93-4 Usage
Description
Tamoxifen acid, also known as Z-[4-(1,2-Diphenyl-1-butenyl)phenoxy]acetic acid, is an acidic metabolite of the estrogenic drug Tamoxifen. It possesses weak acidic properties and is derived from the metabolism of Tamoxifen, a selective estrogen receptor modulator.
Uses
Used in Pharmaceutical Industry:
Tamoxifen acid is used as a pharmaceutical agent for its estrogenic properties. It is particularly effective in treating breast cancer, as it can selectively bind to estrogen receptors and modulate their activity. This helps in inhibiting the growth and progression of estrogen-dependent tumors.
Additionally, tamoxifen acid may have potential applications in other areas of medicine, such as osteoporosis treatment and contraception, due to its ability to interact with estrogen receptors. However, further research is needed to fully understand its potential benefits and risks in these areas.
Check Digit Verification of cas no
The CAS Registry Mumber 97818-93-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,7,8,1 and 8 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 97818-93:
(7*9)+(6*7)+(5*8)+(4*1)+(3*8)+(2*9)+(1*3)=194
194 % 10 = 4
So 97818-93-4 is a valid CAS Registry Number.
InChI:InChI=1/C24H22O3/c1-2-22(18-9-5-3-6-10-18)24(19-11-7-4-8-12-19)20-13-15-21(16-14-20)27-17-23(25)26/h3-16H,2,17H2,1H3,(H,25,26)/b24-22-
97818-93-4Relevant articles and documents
The use of Octafluorotoluene and Pentafluoropyridine in the Synthesis of Pure Z and E Isomers of Derivatives of Tamoxifen -1-butene>
Jarman, Michael,McCague, Raymond
, p. 1342 - 1388 (2007/10/02)
Octafluorotoluene and pentafluoropyridine have been used in the synthesis of pure Z and E isomers of derivatives of the anticancer drug, tamoxifen (1).The isomeric ethers derived by reaction of these perfluoroarenes with an E/Z mixture of 1,2-diphenyl-1-(4-hydroxyphenyl)-1-butene (3) and (4) were easily separated.A process is described for conversion of the E/Z mixtures into one isomer.Cleavage of the ethers regenerated the phenol (3) or (4) of pure stereochemical configuration and the Z-isomer (3) was used for the synthesis of tamoxifen (1) and various monomeric and dimeric analogues.Other perfluoroarenes were less useful.A short synthesis involving early introduction of the perfluorotolyl group is also described.