97853-38-8

Upstream product

• 133286-20-1 (E)-2-[1,3]Dithiolan-2-ylidene-5-(4-methoxy-phenyl)-3-oxo-pent-4-enoic acid 
• 6784-59-4 1-(1,3-dithiolan-2-ylidene)propan-2-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 2080-44-6 ethyl 2-(1,3-dithiolan-2-ylidene)-3-oxobutanoate 
• 133286-38-1 3-[1,3]Dithiolan-2-ylidene-6-(4-methoxy-phenyl)-dihydro-pyran-2,4-dione 
• 133286-42-7 6-(4-methoxyphenyl)dihydro-2H-pyran-2,4(3H)-dione 

Downstream Products

• 1610888-95-3 (E)-4-(1,3-dithiolan-2-ylidene)-5,5,5-trifluoro-1-(4-methoxyphenyl)pent-1-en-3-one 
• 1639790-44-5 (E)-4-(1,3-dithiolan-2-ylidene)-1-(4-methoxyphenyl)hepta-1,6-dien-3-one 
• 97853-44-6 2-(4-Methoxyphenyl)-4-oxo-6,6-ethylendithiohexa-5-ensaeure 
• 1174002-59-5 ethyl 5-(1,3-dithiolan-2-ylidene)-2-(4-methoxyphenyl)-1-nitro-4-oxocyclohexane carboxylate 
• 1142319-77-4 10-(1,3-dithiolan-2-ylidene)-7-(4-methoxyphenyl)-3,3-dimethylspiro[5.5]undecane-1,5,9-trione 
• 1245820-88-5 (2E,6E)-tert-butyl 4-(1,3-dithiolan-2-ylidene)-7-(4-methoxyphenyl)-5-oxohepta-2,6-dienoate 

Relevant academic research and scientific papers

Copper-catalyzed trifluoromethylation of internal olefinic C-H bonds: Efficient routes to trifluoromethylated tetrasubstituted olefins and N-heterocycles

The functionalization of internal olefins has been a challenging task in organic synthesis. Efficient CuII-catalyzed trifluoromethylation of internal olefins, that is, α-oxoketene dithioacetals, has been achieved by using Cu(OH)2 as a catalyst and TMSCF3 as a trifluoromethylating reagent. The push-pull effect from the polarized olefin substrates facilitates the internal olefinic C-H trifluoromethylation. Cyclic and acyclic dithioalkyl α-oxoketene acetals were used as the substrates and various substituents were tolerated. The internal olefinic C-H bond cleavage was not involved in the rate-determining step, and a mechanism that involves radicals is proposed based on a TEMPO-quenching experiment of the trifluoromethylation reaction. Further derivatization of the resultant CF 3 olefins led to multifunctionalized tetrasubstituted CF3 olefins and trifluoromethylated N-heterocycles.

Palladium-catalyzed oxidative heck-type allylation of β,β- disubstituted enones with allyl carbonates

The palladium-catalyzed oxidative Heck-type allylation of β,β-disubstituted enones, i.e., α-oxoketene dithioacetals, was efficiently realized with allyl carbonates, providing a concise route to highly functionalized dienes. The present synthetic methodology utilizes the substrate activation strategy to activate the C-H bond of β,β-disubstituted enones by introduction of a 1,2-dithiolane functionality to make the enone substrate highly polarized and thus increase its reactivity, demonstrating rare examples for transition metal-catalyzed allylic substitution of ss,ss-disubstituted enones through a Heck-type allylation process.

α-alkenoyl ketene S,S-acetal-based multicomponent reaction: An efficient approach for the selective construction of polyfunctionalized cyclohexanones

A versatile multicomponent reaction based on the new four-carbon synthons α-alkenoyl ketene S,S- acetals 1 has been developed. This three-component reaction of readily available α-alkenoyl ketene S,S- acetals 1 with aldehydes 2 and active methylene compou

Dimsyl anion mediated tandem fragmentation cyclization reactions of alkenoyl ketenedithioacetals: A facile synthesis of substituted 2,3-Dihydro-4H-thiopyran-4-ones

Dimsyl sodium induced anionic ring cleavage of 1-(1,3-dithiolane-2-ylidene)-4-aryl-3-butene-2-ones followed by intramolecular cyclisation of the intermediate thiolate anion gave 2-aryl, 6-(vinylsulfanyl)-2,3-dihydro-4H-thiopyran-4-ones in good yields.

A novel route to alkenoyl- and cinnamoylketene dithioacetals

2-Acetyl(ethoxycarbonyl)methylene-1,3-dithietane and -dithiane (1) were condensed with various aldehydes or ketones to afford high yields of the corresponding substituted 2-(1-carboxy-2-oxo-3-butenylidene)-1,3-dithietanes and -dithianes 4, which upon heating decarboxylated smoothly to give the title compounds in high yield.