97856-56-9Relevant articles and documents
Facile preparation of cyclopropanes from 2-iodoethyl-substituted olefins and 1,3-dihalopropanes with zinc powder
Sakuma, Daisuke,Togo, Hideo
, p. 10138 - 10145 (2007/10/03)
Two efficient, simple, cheap, and environmentally benign preparations of cyclopropanes were achieved. One is the formation via 3-exo-trig manner from various electron-deficient 2-iodoethyl-substituted olefins with zinc powder in a mixture of t-butyl alcoh
Practical Stereoselective Synthesis of (2E)- and (2Z)-4-Cycloalkylidenebut-2-enoic Acids
Karagiozov, Stoyan K.,Abbott, Frank S.
, p. 871 - 888 (2007/10/03)
Stereoselective synthesis of α,β-unsaturated esters 7 and 8 was achieved through Horner-Wadsworth-Emmons reaction of β,β -disubstituted α,β-unsaturated aldehydes. Thus, aldehydes 6 undergo olefination with phosphonate carbanion generated from triethyl phosphonoacetate 3 and lithium hydroxide or butyl lithium/DMPU to give (E)-α,β -unsaturated esters 7 with excellent selectivity. The treatment of 6 with the new Horner-Emmons reagents, ethyl(diphenylphosphono)acetate 4a and ethyl (di-o-tolyl-phosphono) acetate 4b in the presence of benzyltrimethyl ammonium hydroxide (Triton B) afforded (Z)-α,β-unsaturated esters 8 with 73-89% selectivity. The esters 7 and 8 were converted to (2E)- and (2Z)-4-cycloalkylidenebut-2-enoic acids 9 and 10, respectively.
A Facile Synthesis of 2,4-Alkadienoic Esters and 2,4,6-Alkatrienoic Esters via Arsonium Ylides
Huang, Yaozeng,Shen, Yanchang,Zheng, Jianhua,Zhang, Shixiang
, p. 57 - 58 (2007/10/02)
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