97856-56-9

Upstream product

• 1713-63-9 cyclohexylideneacetaldehyde 
• 16139-79-0 ethyl diphenylphosphonoacetate 
• 188945-41-7 ethyl di-O-tolylphosphonoacetate 
• 97856-60-5 3-Ethoxycarbonylallylidenetriphenylarsonium bromide 
• 37746-78-4 4-bromo-trans-crotonic acid ethyl ester 
• 108-94-1 cyclohexanone 
• 4435-18-1 2-cyclohexylideneacetonitrile 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 59425-01-3 ethyl (E)-4-iodobut-2-enoate 
• 71-43-2 benzene 
• 97856-61-6 3-Ethoxycarbonylallylidenetriphenylarsorane 

Downstream Products

• 4351-03-5 (E)-5-cyclohexylidene-2,4-pentadienal 
• 190667-85-7 C₁₀H₁₆O 
• 4351-05-7 (2E)-5-cyclohexyl-2,4-pentadienoic acid 
• 5662-93-1 (2E)-4-cyclopentylidenebut-2-enoic acid 
• 690965-98-1 (2E)-4-cycloheptylidenebut-2-enoic acid 
• 690965-99-2 (2E)-4-cyclooctylidenebut-2-enoic acid 

Relevant academic research and scientific papers

Facile preparation of cyclopropanes from 2-iodoethyl-substituted olefins and 1,3-dihalopropanes with zinc powder

Two efficient, simple, cheap, and environmentally benign preparations of cyclopropanes were achieved. One is the formation via 3-exo-trig manner from various electron-deficient 2-iodoethyl-substituted olefins with zinc powder in a mixture of t-butyl alcoh

Facile and environmentally benign Zn-mediated cyclopropanation of electron-deficient 2-iodoethyl-substituted olefins via radical 3-exo-trig manner

An efficient, simple, cheap, and environmentally benign preparation of cyclopropanes via 3-exo-trig manner from various electron-deficient 2-iodoethyl-substituted olefins with zinc powder in a mixture of f-butyl alcohol and water was achieved.

Practical Stereoselective Synthesis of (2E)- and (2Z)-4-Cycloalkylidenebut-2-enoic Acids

Stereoselective synthesis of α,β-unsaturated esters 7 and 8 was achieved through Horner-Wadsworth-Emmons reaction of β,β -disubstituted α,β-unsaturated aldehydes. Thus, aldehydes 6 undergo olefination with phosphonate carbanion generated from triethyl phosphonoacetate 3 and lithium hydroxide or butyl lithium/DMPU to give (E)-α,β -unsaturated esters 7 with excellent selectivity. The treatment of 6 with the new Horner-Emmons reagents, ethyl(diphenylphosphono)acetate 4a and ethyl (di-o-tolyl-phosphono) acetate 4b in the presence of benzyltrimethyl ammonium hydroxide (Triton B) afforded (Z)-α,β-unsaturated esters 8 with 73-89% selectivity. The esters 7 and 8 were converted to (2E)- and (2Z)-4-cycloalkylidenebut-2-enoic acids 9 and 10, respectively.

VALPROIC ACID ANALOGUES AND PHARMACEUTICAL COMPOSITIONS THEREOF

Analogues of valproic acid useful in treating neuroaffective disorders including convulsions, bipolar disorder, and migraine headache are disclosed. The analogues are halide substituted analogues, cyclic analogues, and conjugated diene analogues of valproic acid. Pharmaceutical compositions or prodrugs containing the analogues or pharmaceutically acceptable salts thereof are disclosed. Methods of making the compounds and treating mammals with neuroaffective disorders are also disclosed.