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FLUORINE-CONTAINING AMINO ACIDS AND THEIR DERIVATIVES. 6. AN EFFICIENT SYNTHESIS OF β-FLUORINATED ALANINES VIA FLUOROHALOMETHYLATION OF AMINOMALONATES
Tsushima, Tadahiko,Kawada, Kenji
, p. 2445 - 2448 (1985)
Aminomalonates, e.g., 1 and 2, smoothly reacted with difluoro- and chlorofluorocarbene to produce the adducts (3, 4, and 5) in good yields.These products were successfully converted to various versatile β-fluorinated alanine derivatives, i.e., β,β-difluor
