FLUORINE-CONTAINING AMINO ACIDS AND THEIR DERIVATIVES. 6. AN EFFICIENT SYNTHESIS OF β-FLUORINATED ALANINES VIA FLUOROHALOMETHYLATION OF AMINOMALONATES

Article abstract of DOI:10.1016/S0040-4039(00)94849-4

Aminomalonates, e.g., 1 and 2, smoothly reacted with difluoro- and chlorofluorocarbene to produce the adducts (3, 4, and 5) in good yields.These products were successfully converted to various versatile β-fluorinated alanine derivatives, i.e., β,β-difluor