97936-44-2

Basic information

• Product Name: 2-[(4-CHLOROPHENYL)THIO]PYRIDINE-3-CARBONYL CHLORIDE
• Synonyms: BUTTPARK 97\12-70;2-[(4-CHLOROPHENYL)THIO]PYRIDINE-3-CARBONYL CHLORIDE;2-[(4-Chlorophenyl)sulfonyl]3-methylthiophene-2-carbonyl chloride;2-[(4-Chlorophenyl)thio]pyridine-3-carbonyl chloride, 95+%;2-((4-chlorophenyl)thio)nicotinoyl chloride
• CAS NO: 97936-44-2
• Molecular Formula: C₁₂H₇Cl₂NOS
• Molecular Weight: 284.16
• Mol File: 97936-44-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 100 °C
• Boiling Point: 407.6°Cat760mmHg
• Flash Point: 200.3°C
• Appearance: /
• Density: 1.47g/cm³
• Vapor Pressure: 7.46E-07mmHg at 25°C
• Refractive Index: 1.665
• CAS DataBase Reference: 2-[(4-CHLOROPHENYL)THIO]PYRIDINE-3-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-CHLOROPHENYL)THIO]PYRIDINE-3-CARBONYL CHLORIDE(97936-44-2)
• EPA Substance Registry System: 2-[(4-CHLOROPHENYL)THIO]PYRIDINE-3-CARBONYL CHLORIDE(97936-44-2)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3261
• Hazardous Substances Data: 97936-44-2(Hazardous Substances Data)

Usage

General Description

2-[(4-Chlorophenyl)thio]pyridine-3-carbonyl chloride is a chemical compound with the molecular formula C12H7Cl2NO2S. It is a derivative of pyridine and contains a thioether group. 2-[(4-CHLOROPHENYL)THIO]PYRIDINE-3-CARBONYL CHLORIDE is a carbonyl chloride, which means it contains both a carbonyl group and a chlorine atom. It is commonly used in organic synthesis as a reagent for the formation of new carbon-carbon and carbon-heteroatom bonds. Its reactive carbonyl chloride group makes it useful in the production of various pharmaceuticals, agrochemicals, and materials. As a chlorinated aromatic compound, it should be handled and stored with appropriate safety precautions due to its potential hazards.

InChI:InChI=1/C12H7Cl2NOS/c13-8-3-5-9(6-4-8)17-12-10(11(14)16)2-1-7-15-12/h1-7H

Upstream product

• 106-54-7 p-Chlorothiophenol 
• 97936-26-0 N-Benzothiazol-2-yl-2-(4-chloro-phenylsulfanyl)-nicotinamide 
• 955-54-4 2-<(4-chlorophenyl)thio>nicotinic acid 

Downstream Products

• 97936-25-9 2-(4-Chloro-phenylsulfanyl)-N-thiazol-2-yl-nicotinamide 
• 97936-27-1 2-(4-Chloro-phenylsulfanyl)-N-pyridin-2-yl-nicotinamide 
• 639514-48-0 C₂₁H₁₉ClN₂O₅S₂ 
• 97936-34-0 2-(4-Chloro-phenylsulfanyl)-N-(2,6-dimethyl-phenyl)-nicotinamide 
• 97936-26-0 N-Benzothiazol-2-yl-2-(4-chloro-phenylsulfanyl)-nicotinamide 
• 153143-99-8 2-<(4-chlorophenyl)thio>nicotinoyl azide 

Relevant articles and documents

Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: Synthesis and neurochemical study

In order to characterize the pharmacological profile of the different chemical classes of pyridobenzazepine derivatives, a series of N- methylpiperazinopyrido[1,4]- and -[1,5]- benzoxa- and benzothiazepine derivatives were prepared. The affinities for D2, D1, 5-HT2, and cholinergic (M) receptors were measured. In comparison to dibenzazepine reference compounds, a strong decrease of the affinities was observed, less pronounced, however, for the substituted analogues. Oxazepine and thiazepine analogues like clozapine (except 8-chloro-6-(4-methylpiperazin-1-yl)- pyrido[2,3-b][1,4]benzoxazepine (9) and 8-chloro-6-(4-methylpiperazin-1- yl)pyrido[2,3-b][1,4]-benzothiazepine (11)) were found to be inactive against apomorphine stereotypies. In the open-field test in rats, different molecules showed a high disinhibitory activity as observed with anxiolytic drugs. Moreover, 8-chloro-5-(4-methylpiperazin-1-yl)pyrido[2,3-b][1,5]benzoxazepine (14) presented a clozapine-like profile that was confirmed in the behavioral model in dogs and showed most of the behavioral characteristics described for antipsychotic drugs. Its neurochemical profile, in particular the 5-HT2/D2 ratio, was also compatible with atypical antipsychotic activity.