97936-44-2

Usage

Uses

Used in Pharmaceutical Industry:
2-[(4-Chlorophenyl)thio]pyridine-3-carbonyl chloride is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to form new chemical bonds that can enhance the activity and selectivity of drug molecules.
Used in Agrochemical Industry:
In the agrochemical sector, 2-[(4-Chlorophenyl)thio]pyridine-3-carbonyl chloride serves as a building block in the development of new pesticides and herbicides, leveraging its reactivity to create compounds with specific pesticidal properties.
Used in Material Science:
2-[(4-Chlorophenyl)thio]pyridine-3-carbonyl chloride is utilized as a precursor in the creation of advanced materials, where its unique structural features contribute to the desired material properties, such as conductivity or stability.
Each application takes advantage of the compound's reactivity and structural attributes to achieve specific goals in their respective fields, underscoring its importance in modern chemical research and development.

InChI:InChI=1/C12H7Cl2NOS/c13-8-3-5-9(6-4-8)17-12-10(11(14)16)2-1-7-15-12/h1-7H

Upstream product

• 106-54-7 p-Chlorothiophenol 
• 97936-26-0 N-Benzothiazol-2-yl-2-(4-chloro-phenylsulfanyl)-nicotinamide 
• 955-54-4 2-<(4-chlorophenyl)thio>nicotinic acid 

Downstream Products

• 97936-25-9 2-(4-Chloro-phenylsulfanyl)-N-thiazol-2-yl-nicotinamide 
• 153143-99-8 2-<(4-chlorophenyl)thio>nicotinoyl azide 
• 639514-48-0 C₂₁H₁₉ClN₂O₅S₂ 
• 97936-26-0 N-Benzothiazol-2-yl-2-(4-chloro-phenylsulfanyl)-nicotinamide 
• 97936-34-0 2-(4-Chloro-phenylsulfanyl)-N-(2,6-dimethyl-phenyl)-nicotinamide 
• 97936-27-1 2-(4-Chloro-phenylsulfanyl)-N-pyridin-2-yl-nicotinamide 

Relevant academic research and scientific papers

Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: Synthesis and neurochemical study

In order to characterize the pharmacological profile of the different chemical classes of pyridobenzazepine derivatives, a series of N- methylpiperazinopyrido[1,4]- and -[1,5]- benzoxa- and benzothiazepine derivatives were prepared. The affinities for D2, D1, 5-HT2, and cholinergic (M) receptors were measured. In comparison to dibenzazepine reference compounds, a strong decrease of the affinities was observed, less pronounced, however, for the substituted analogues. Oxazepine and thiazepine analogues like clozapine (except 8-chloro-6-(4-methylpiperazin-1-yl)- pyrido[2,3-b][1,4]benzoxazepine (9) and 8-chloro-6-(4-methylpiperazin-1- yl)pyrido[2,3-b][1,4]-benzothiazepine (11)) were found to be inactive against apomorphine stereotypies. In the open-field test in rats, different molecules showed a high disinhibitory activity as observed with anxiolytic drugs. Moreover, 8-chloro-5-(4-methylpiperazin-1-yl)pyrido[2,3-b][1,5]benzoxazepine (14) presented a clozapine-like profile that was confirmed in the behavioral model in dogs and showed most of the behavioral characteristics described for antipsychotic drugs. Its neurochemical profile, in particular the 5-HT2/D2 ratio, was also compatible with atypical antipsychotic activity.

Synthesis and diuretic activity of pyrido[2,3-d]pyrimidones and related compounds

The synthesis of a series of pyrido[2,3-d]pyrimidine-4-one derivatives (7) and the results of a study of their potassium-sparing diuretic activity are described. Compounds 7 were prepared from 2-chloro-3-pyridinecarbonyl chloride, 1,2-dihydro-2-thioxo-3-pyridinecarbonyl chloride, 2-methylthio-3-pyridinecarbonyl chloride or 2-(p-chlorophenyl)thio-3-pyridinecarbonylchloride and different amines through the respective amides (4). Compounds 4 and 7 were assayed for diuretic and potassium-sparing activities. Although some of the compounds showed significant diuretic activity, a significant increase of the Na+/K+ index was only observed with 5-oxo-5H(1,3)thiazolo[3,2-a]pyrido[3,2-e]pyrimidine.