955-54-4

Usage

Uses

Used in Pharmaceutical Research:
2-(4-Chlorophenylthio)nicotinic acid is used as a precursor in the synthesis of pharmaceuticals for its unique chemical structure and properties. It may contribute to the development of new drugs with specific therapeutic effects.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-(4-chlorophenylthio)nicotinic acid is utilized for studying biological and biochemical processes related to nicotinic acid and its derivatives. Its involvement aids in understanding the mechanisms of action and potential therapeutic applications of nicotinic acid-related compounds.
Used in Biochemical Studies:
2-(4-Chlorophenylthio)nicotinic acid serves as a valuable tool in biochemical research, where it is used to investigate the roles and interactions of nicotinic acid and its derivatives in cellular processes. This can lead to insights into the development of targeted therapies and interventions for various diseases and conditions.

InChI:InChI=1/C12H8ClNO2S/c13-8-3-5-9(6-4-8)17-11-10(12(15)16)2-1-7-14-11/h1-7H,(H,15,16)/p-1

Upstream product

• 97936-26-0 N-Benzothiazol-2-yl-2-(4-chloro-phenylsulfanyl)-nicotinamide 
• 2942-59-8 2-chloronicotinic acid 
• 106-54-7 p-Chlorothiophenol 

Downstream Products

• 97936-34-0 2-(4-Chloro-phenylsulfanyl)-N-(2,6-dimethyl-phenyl)-nicotinamide 
• 97936-25-9 2-(4-Chloro-phenylsulfanyl)-N-thiazol-2-yl-nicotinamide 
• 97936-27-1 2-(4-Chloro-phenylsulfanyl)-N-pyridin-2-yl-nicotinamide 
• 97936-44-2 2-<(4-chlorophenyl)thio>nicotinic acid chloride 
• 153143-99-8 2-<(4-chlorophenyl)thio>nicotinoyl azide 

Relevant academic research and scientific papers

Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: Synthesis and neurochemical study

In order to characterize the pharmacological profile of the different chemical classes of pyridobenzazepine derivatives, a series of N- methylpiperazinopyrido[1,4]- and -[1,5]- benzoxa- and benzothiazepine derivatives were prepared. The affinities for D2, D1, 5-HT2, and cholinergic (M) receptors were measured. In comparison to dibenzazepine reference compounds, a strong decrease of the affinities was observed, less pronounced, however, for the substituted analogues. Oxazepine and thiazepine analogues like clozapine (except 8-chloro-6-(4-methylpiperazin-1-yl)- pyrido[2,3-b][1,4]benzoxazepine (9) and 8-chloro-6-(4-methylpiperazin-1- yl)pyrido[2,3-b][1,4]-benzothiazepine (11)) were found to be inactive against apomorphine stereotypies. In the open-field test in rats, different molecules showed a high disinhibitory activity as observed with anxiolytic drugs. Moreover, 8-chloro-5-(4-methylpiperazin-1-yl)pyrido[2,3-b][1,5]benzoxazepine (14) presented a clozapine-like profile that was confirmed in the behavioral model in dogs and showed most of the behavioral characteristics described for antipsychotic drugs. Its neurochemical profile, in particular the 5-HT2/D2 ratio, was also compatible with atypical antipsychotic activity.

Synthesis and diuretic activity of pyrido[2,3-d]pyrimidones and related compounds

The synthesis of a series of pyrido[2,3-d]pyrimidine-4-one derivatives (7) and the results of a study of their potassium-sparing diuretic activity are described. Compounds 7 were prepared from 2-chloro-3-pyridinecarbonyl chloride, 1,2-dihydro-2-thioxo-3-pyridinecarbonyl chloride, 2-methylthio-3-pyridinecarbonyl chloride or 2-(p-chlorophenyl)thio-3-pyridinecarbonylchloride and different amines through the respective amides (4). Compounds 4 and 7 were assayed for diuretic and potassium-sparing activities. Although some of the compounds showed significant diuretic activity, a significant increase of the Na+/K+ index was only observed with 5-oxo-5H(1,3)thiazolo[3,2-a]pyrido[3,2-e]pyrimidine.