97938-48-2

Upstream product

• 34906-12-2 2-formyl-1,3-dithiane 
• 97938-56-2 1-bromo-3-phenylpent-2-ene 
• 93-55-0 1-phenyl-propan-1-one 
• 31254-19-0 1-Ethyl-1-phenylallyl alcohol 

Downstream Products

• 89012-52-2 (RS)-3-ethyl-3-phenylpent-4-enal 
• 97938-55-1 2-((E)-3-Phenyl-pent-2-enyl)-[1,3]dithiane-2-carbaldehyde 

Relevant academic research and scientific papers

The synthesis and characterization of 3,3-disubstituted pent-4-enals and their 2,2-(trimethylendithio)pent-4-enal precursors, including the X-ray crystal structure of (R)-3-ethyl-3-phenyl-2,2-(trimethylenedithio)pent-4-enal

A variety of 3,3-disubstituted pent-4-enals (5a, R=Me, R'=Et; 5b, R=Me, R'=Ph; 5c, R=Et, R'=Ph) has been prepared by the Raney nickel desulfurization of the corresponding 3,3-disubstituted 2,2-(trimethylenedithio)pent-4-enal precursors 4a-4c.The precursor compounds were prepared by the alkylation of 2-formyl-1,3-dithiane with the appropriate 3,3-disubstituted allylic bromide.The new compounds have been characterized by elemental analysis, infrared and nmr spectroscopy, and mass spectrometry.The crystal and molecular structure of (R)-4c has also been determined by X-ray crystallography.At temperatures of ca. 130 deg C, compounds 4a-4c undergo intramolecular rearrangement to form the trisubstituted alkenes 6a-6c, which have also been characterized by the present study.