97945-28-3Relevant academic research and scientific papers
A convenient synthesis of highly conjugated 5-nitroimidazoles
Benakli, Kamel,Terme, Thierry,Maldonado, Jose,Vanelle, Patrice
, p. 1689 - 1695 (2007/10/03)
A new series of highly conjugated 5-nitroimidazoles was prepared using electron transfer methodology in multi-steps synthesis from 2-chloromethyl-1-methyl-5-nitro-1H-imidazole.
Synthesis of tetrasubstituted ethylenic compounds from a gem- trichloroimidazole derivative by electron transfer reactions
Vnelle, Patrice,Benakli, Kamel,Giraud, Luc,Crozet, Michel P.
, p. 801 - 803 (2007/10/03)
New 5-nitroimidazoles beating a tetrasubstituted ethylenic double bond in 2-position were synthesized in high yields by the reaction of secondary nitronate anions with a new reductive alkylating agent, 1-methyl-2- trichloromethyl-5-nitroimidazole. Consecutive S(RN)1 and E(RC)1 mechanisms were followed in these processes.
S(RN)1 synthesis of new 5-nitroimidazoles highly active against protozoa and anaerobes
Vanelle,Crozet,Maldonado,Barreau
, p. 167 - 178 (2007/10/02)
1-Methyl-2-chloromethyl-5-nitroimidazole reacts by an S(RN)1 mechanism with various aliphatic, cyclic or heterocyclic nitronate anions to afford, in high yields, new 5-nitroimidazoles bearing a trisubstituted ethylenic double bond at the 2 position. Some of these compounds are as active as metronidazole in vitro and in vivo against protozoa and anaerobic bacteria. Structure-activity relationships are discussed.
REACTIONS SRN1 EN SERIE HETEROCYCLIQUE: II. REACTIVITE DU METHYL-1 CHLOROMETHYL-2 NITRO-5 IMIDAZOLE.
Crozet, Michel P.,Surzur, Jean-Marie,Vanelle, Patrice,Ghiglione, Claude,Maldonado, Jose
, p. 1023 - 1026 (2007/10/02)
1-Methyl-2-chloromethyl-5-nitroimidazole reacts with tertiary nitronate anions in excess to afford in high yields the previously unknown 1-methyl-5-nitro-imidazoles bearing a trisubstituted ethylenic double bond in the 2 position.These compounds are ascri
