6905-07-3

Basic information

• Product Name: 2-(chloroMethyl)-1-Methyl-5-nitro-1H-iMidazole
• Synonyms: 2-(chloroMethyl)-1-Methyl-5-nitro-1H-iMidazole
• CAS NO: 6905-07-3
• Molecular Formula: C₅H₆ClN₃O₂
• Molecular Weight: 175.57304
• Mol File: 6905-07-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(chloroMethyl)-1-Methyl-5-nitro-1H-iMidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(chloroMethyl)-1-Methyl-5-nitro-1H-iMidazole(6905-07-3)
• EPA Substance Registry System: 2-(chloroMethyl)-1-Methyl-5-nitro-1H-iMidazole(6905-07-3)

Safety Data

• Hazardous Substances Data: 6905-07-3(Hazardous Substances Data)

Usage

General Description

2-(Chloromethyl)-1-methyl-5-nitro-1H-imidazole is a chemical compound with the molecular formula C6H7ClN4O2. It is an imidazole derivative with a nitro group and a chloromethyl group attached to the carbon ring. 2-(chloroMethyl)-1-Methyl-5-nitro-1H-iMidazole is used in the pharmaceutical industry as an intermediate for the synthesis of various drugs, particularly for antiprotozoal agents. It has also been studied for its potential use as an antimicrobial agent due to its ability to inhibit the growth of certain bacteria and parasites. Additionally, 2-(Chloromethyl)-1-methyl-5-nitro-1H-imidazole has been investigated for its potential anti-cancer properties, showing promise in inhibiting the growth of certain tumor cells.

Downstream Products

• 139157-69-0 1-methyl 2-(2,2-dimethyl 1,3-dioxane 5-ylidenemethyl) 5-nitroimidazole 
• 60768-39-0 3-(1-methyl-5-nitro-1H-imidazol-2-ylmethoxy)-benzonitrile 
• 60768-34-5 1-methyl-5-nitro-2-(3-nitrophenoxymethyl)-1H-imidazole 
• 60768-32-3 4-(1-methyl-5-nitro-1H-imidazol-2-ylmethoxy)-benzonitrile 
• 64580-33-2 1-methyl-2-(3-methyl-4-nitro-phenoxymethyl)-5-nitro-1H-imidazole 
• 60768-35-6 2-(2-chloro-4-nitro-phenoxymethyl)-1-methyl-5-nitro-1H-imidazole 
• 59729-37-2 1-methyl-2-{[(4-methylsulfanyl)phenoxy]methyl}-5-nitro-1H-imidazole 
• 64570-20-3 2-(4-methanesulfonyl-3-methyl-phenoxymethyl)-1-methyl-5-nitro-1H-imidazole 
• 60768-36-7 2-(4-chloro-2-nitro-phenoxymethyl)-1-methyl-5-nitro-1H-imidazole 
• 60768-37-8 2-((2,4-dinitrophenoxy)methyl)-1-methyl-5-nitro-1H-imidazole 
• 64580-34-3 2-methyl-4-(1-methyl-5-nitro-1H-imidazol-2-ylmethoxy)-benzonitrile 
• 60768-33-4 1-methyl-5-nitro-2-(2-nitro-phenoxymethyl)-1H-imidazole 
• 60768-38-9 2-(1-methyl-5-nitro-1H-imidazol-2-ylmethoxy)-benzonitrile 
• 60768-31-2 1-methyl-5-nitro-2-(4-nitrophenoxymethyl)-1H-imidazole 

Relevant articles and documents

Oxidative decarbonylation of β-arylpyruvic acids using sodium perborate

Oxidation of β-aryl- and β-heteroarylpyruvic acids using sodium perborate tetrahydrate (SPB) in aqueous solution at ambient temperature gives the corresponding arylacetic acids in good yield (68-86%). The mild conditions are convenient for the preparation of thermally unstable acids. In particular the method has been applied to the preparation of an unstable 5- nitroimidazol-2-yl ethanoic acid which could not be obtained using other reagents apparently due to enolisation of the pyruvic acid precursor. Attempts to achieve decarbonylation using calcium hypochlorite or SPB in acidic solution lead to the 2 chloromethyl derivatives. The novel 5- nitroimidazol-2-yl ethanoic acid, which was required as a precursor of molecules of biological interest, has been fully characterised and converted to a known amide. Reaction of this acid with Vilsmeier's reagent gave an enamine derivative and not the expected vinamidinium salt. This novel mode of reaction is attributable to intramolecular hydrogen-bonding and favourable conjugation.