97945-38-5

Usage

Uses

Used in Organic Synthesis:
Tetrahydro-2-(2-nitropropoxy)-2H-pyran is used as a key intermediate in organic synthesis for the production of various chemical compounds. Its unique structure allows it to participate in a variety of chemical reactions, such as nucleophilic substitutions, eliminations, and rearrangements, which are essential for the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Tetrahydro-2-(2-nitropropoxy)-2H-pyran is utilized as a building block for the development of new drugs and medicinal compounds. Its ability to undergo various chemical transformations makes it a valuable asset in the synthesis of bioactive molecules with potential therapeutic applications.
Used in Agrochemical Industry:
Tetrahydro-2-(2-nitropropoxy)-2H-pyran also finds application in the agrochemical industry, where it is used in the synthesis of pesticides, herbicides, and other crop protection agents. Its reactivity and compatibility with other chemical groups make it suitable for the development of effective and environmentally friendly agrochemical products.
Used in Material Science:
In the field of material science, Tetrahydro-2-(2-nitropropoxy)-2H-pyran is employed in the synthesis of advanced materials with specific properties, such as polymers, coatings, and adhesives. Its ability to form stable linkages with other molecules contributes to the development of materials with improved performance characteristics.
Used in Dye and Pigment Industry:
Tetrahydro-2-(2-nitropropoxy)-2H-pyran is also utilized in the dye and pigment industry for the synthesis of colorants and dyes with unique properties. Its chemical structure allows for the creation of dyes with specific color profiles and stability, which are essential for various applications, including textiles, plastics, and printing inks.

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 2902-96-7 2-NITROPROPANOL 
• 71-30-7 Cytosine 
• 86958-48-7 2-(2-Chloro-2-nitro-propoxy)-tetrahydro-pyran 
• 109178-34-9 2-(2-Bromo-2-nitro-propoxy)-tetrahydro-pyran 

Downstream Products

• 86958-69-2 2-[(E)-2-Methyl-3-(4-nitro-phenyl)-allyloxy]-tetrahydro-pyran 
• 86958-63-6 2-[2-Methyl-2-nitro-3-(4-nitro-phenyl)-propoxy]-tetrahydro-pyran 
• 117377-04-5 1-{5-[1-Methyl-1-nitro-2-(tetrahydro-pyran-2-yloxy)-ethyl]-2-phenyl-[1,3]dioxan-5-yl}-1H-imidazole 
• 117377-04-5 1-{5-[1-Methyl-1-nitro-2-(tetrahydro-pyran-2-yloxy)-ethyl]-2-phenyl-[1,3]dioxan-5-yl}-1H-imidazole 
• 117377-04-5 1-{5-[1-Methyl-1-nitro-2-(tetrahydro-pyran-2-yloxy)-ethyl]-2-phenyl-[1,3]dioxan-5-yl}-1H-imidazole 
• 86958-48-7 2-(2-Chloro-2-nitro-propoxy)-tetrahydro-pyran 
• 29342-38-9 1-nitro-1-(4-nitrophenyl)ethane 
• 100-19-6 (4-nitrophenyl)ethanone 

Relevant academic research and scientific papers

Synthesis and spin trapping properties of polystyrene supported trifluoromethylated cyclic nitrones

Polystyrene supported fluorinated cyclic nitrone spin-traps: Resin-2-HFDMPO (2-hydroxymethyl-2-methyl-5-(trifluoromethyl)-3,4-dihydro-2H-pyrrole-1-oxide) and Resin-2-PFDMPO (2-(3-hydroxypropyl)-2-methyl-5-(trifluoromethyl)-3,4-dihydro-2H-pyrrole 1-oxide) containing a trifluoromethyl pyrroline-N-oxide core were developed to detect free radicals under flow conditions. A continuous flow EPR technique was used to evaluate the spin trapping properties of these tethered nitrones. While both resins trapped radicals, polymer supported nitrone Resin-2-PFDMPO with a longer and more flexible linker showed a more information rich spectrum than Resin-2-HFDMPO.

Synthesis and characterization of 5-hydroxymethyl-5-methyl-pyrroline N-oxide and its derivatives

Synthesis and spin trapping behavior of three novel DMPO derivatives, namely 5-hydroxymethyl-5-methyl-pyrroline N-oxide (HMMPO), 5-(2-furanyl)- oxymethyl-5-methyl-pyrroline N-oxide (FMMPO), and 5-(2-pyranyl)-oxymethyl-5- methyl-pyrroline N-oxide (PMMPO) towards different oxygen- and carbon-centered radicals are described. The stabilizing effect of a series of cyclodextrins on the superoxide adducts was tested.

Selective N1-alkylation of pyrimidine bases via radical (S(RN)1) mechanism

Under photostimulated S(RN)1 conditions the cytosine nitranion behaves as a nucleophile toward the carbon radical generated from gem halonitro, or gem dinitroalcane derivatives to give regiospecifically the N-1 alkyled cytosine compound which is representative of a new series of cytosine acyclonucleosides. Uracile and its 5-fluoro or 5-nitro analogs fail to react and thymine gives an unexpected disubstituted S(RN)1 product whose formation is discussed.

S(RN)1 synthesis of new 5-nitroimidazoles highly active against protozoa and anaerobes

1-Methyl-2-chloromethyl-5-nitroimidazole reacts by an S(RN)1 mechanism with various aliphatic, cyclic or heterocyclic nitronate anions to afford, in high yields, new 5-nitroimidazoles bearing a trisubstituted ethylenic double bond at the 2 position. Some of these compounds are as active as metronidazole in vitro and in vivo against protozoa and anaerobic bacteria. Structure-activity relationships are discussed.

SUR LA REACTIVITE DE gem-BROMONITROALCANES EN PRESENCE DE THIOLATES.

Reactions between various gem-bromonitro alcanes BrA1'-4 in the presence of t-C4H9S(1-) are shown to proceed at low temperature via either both radical coupling and SRN1 or radical coupling only and to lead efficiently to (A1'-4)2.

Direct and Efficient Preparation of gem-Chloronitro Compounds or Nitro Compounds from gem-Bromonitro Compounds

Sodiumethanethiolate in methanol is an efficient reducing agent for gem-bromonitro compounds; treatment of the resultant nitronates with a protic acid or with N-chlorosuccinimide gives high yields of the corresponding nitro or gem-chloronitro compounds, respectively.