97961-95-0Relevant academic research and scientific papers
Et3SiH + KO: T Bu provide multiple reactive intermediates that compete in the reactions and rearrangements of benzylnitriles and indolenines
Arokianathar, Jude N.,Clark, Kenneth F.,Dimitrova, Daniela,Leach, Stuart G.,Murphy, John A.,Poole, Darren L.,Smith, Andrew J.
, p. 12364 - 12370 (2020/12/08)
The combination of potassium tert-butoxide and triethylsilane is unusual because it generates multiple different types of reactive intermediates simultaneously that provide access to (i) silyl radical reactions, (ii) hydrogen atom transfer reactions to cl
Single-operation deracemization of 3H-indolines and tetrahydroquinolines enabled by phase separation
Lackner, Aaron D.,Samant, Andrew V.,Toste, F. Dean
, p. 14090 - 14093 (2013/10/21)
The single-operation deracemization of 3H indolines and tetrahydroquinolines is described. An asymmetric redox approach was employed, in which a phosphoric acid catalyst, oxidant, and reductant are present in the reaction mixture. The simultaneous presence of both oxidant and reductant was enabled by phase separation and resulted in the isolation of highly enantioenriched starting materials in high yields.
SYNTHESIS OF 1'-(3-DIMETHYLAMINOPROPYL)-2'-SUBSTITUTED SPIRO.
Rodriguez, Jose-Gonzalo,Temprano, Fernando
, p. 3243 - 3248 (2007/10/02)
Reactivity of the C=N bond in spiro has been analysed.Indolines were obtained in practically quantitative yield using organomagnesium reagents in the presence of copper(I) chloride in toluene at 120 deg C.On the basis of an an
REACTION OF SPIRO WITH GRIGNARD REAGENTS IN THE PRESENCE OF CUPROUS CHLORIDE
Rodriguez, Gonzalo,Benito, Yolanda,Temprano, Fernando
, p. 427 - 428 (2007/10/02)
Attack of MeMgI and PhMgBr in toluene on spiro (1) in the presence of Cu2Cl2 gives 2'-substituted spiro in quantitative yields.Also, attack of PhCH2CH2MgBr on 1 in the presence of Cu2Cl2 afforded 2'-phenethyl, 2'-H and 2'-benzyl (or 2'-p-xylyl) derivatives in toluene (or p-xylene) as solvent.
