97965-89-4Relevant academic research and scientific papers
Iodobenzene diacetate (PIDA)/Zn(II)-mediated oxidation and cleavage of C-C bond: Formation of substituted N-aryl carbamoyl methyl diacetates and derivatives from 3-oxo-butanamides
Wenjun, Hu,Zhaohui, Deng,Chen, Cui,Liu, Wei-Bing
, p. 571 - 572,2 (2020/09/16)
Various substituted N-aryl carbamoyl methyl diacetates have been synthesized from N-aryl-3-oxobutanamides via a diacetoxylation mediated by the combination of iodobenzene diacetate (PIDA)/Zn(OAc)2. This provides a new convenient method to form C-O bonds and cleave C-C bonds. Ten examples were obtained from easily available materials in good to excellent yields.
An improved synthesis of isonitrosoacetanilides
Rewcastle, Gordon W.,Sutherland, Hamish S.,Weir, Claudette A.,Blackburn, Adrian G.,Denny, William A.
, p. 8719 - 8721 (2007/10/03)
A novel two-step synthesis of isonitrosoacetanilides [2-(hydroxyimino)-N- phenylacetamides] has been developed, involving the initial acylation of aniline derivatives with 2,2-diacetoxyacetyl chloride, followed by reaction with hydroxylamine hydrochloride. The method works equally well with a variety of different aniline derivatives, including those with poor aqueous solubility and those containing electron rich ortho-substituents, neither of which react well under traditional conditions.
