97966-10-4Relevant academic research and scientific papers
Synthesis of Picenadol via Metalloenamine Alkylation Methodology
Barnett, Charles J.,Copley-Merriman, Catherine R.,Maki, James
, p. 4795 - 4800 (2007/10/02)
A convenient synthesis of the novel phenylpiperidine analgesic agent picenadol, (+/-)-1, via tetrahydropyridine 2 is described.Tetrahydropyridine 7, prepared from 6 via metalation (n-butyllithium) and alkylation with 1-bromopropane, could not be directly
