97966-11-5

Upstream product

• 1445-73-4 1-Methyl-4-piperidone 
• 2398-37-0 3-methoxyphenyl bromide 
• 73224-20-1 (+/-)-4-(3-methoxyphenyl)-1-methyl-4-piperidinol 
• 97966-10-4 1,2,3,4-tetrahydro-4-(3-methoxyphenyl)-1-methyl-4-propylpyridine 
• 73224-22-3 1-methyl-4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine 
• 50-00-0 formaldehyd 
• 124-40-3 dimethyl amine 
• 33797-51-2 eschenmoser's salt 

Downstream Products

• 79201-85-7 picenadol 
• 79201-85-7 3-((3R,4R)-1,3-Dimethyl-4-propyl-piperidin-4-yl)-phenol 
• 97966-12-6 picenadol methyl ether 
• 97966-12-6 (3R,4R)-4-(3-Methoxy-phenyl)-1,3-dimethyl-4-propyl-piperidine 

Relevant academic research and scientific papers

Synthesis of Picenadol via Metalloenamine Alkylation Methodology

A convenient synthesis of the novel phenylpiperidine analgesic agent picenadol, (+/-)-1, via tetrahydropyridine 2 is described.Tetrahydropyridine 7, prepared from 6 via metalation (n-butyllithium) and alkylation with 1-bromopropane, could not be directly

Processes for preparing picenadol precursors and novel intermediates thereof

The present invention relates to processes for preparing precursors of picenadol, (±)3-(1,3α-dimethyl-4α-propyl-4β-piperidinyl)phenol, hydrochloride, a known analgesic. Certain of the compounds prepared by the present process are novel as well.