97968-17-7

Upstream product

• 122-84-9 4-methoxybenzyl methyl ketone 
• 3471-32-7 4-Methoxyphenylhydrazine 
• 191725-57-2 1-methoxy-4-(1-methoxyprop-1-en-2-yl)benzene 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 97968-22-4 5-Methoxy-3-(4-methoxy-phenyl)-1,2-dimethyl-1H-indole 
• 97968-31-5 Acetic acid 3-(4-acetoxy-phenyl)-1,2-dimethyl-1H-indol-5-yl ester 

Relevant academic research and scientific papers

FeCl3 catalyzed intermolecular reaction between enol ethers and anilines: Access to 2,3-substituted indoles through aryl group migration

An intermolecular FeCl3 catalyzed reaction between anilines and enol ethers is described. A variety of enol ethers and aromatic amines undergo a C[sbnd]C bond formation followed by cyclization via C[sbnd]N bond formation to afford the 2,3-disubstituted indoles, involving an unexpected aryl group migration. In this methodology, anilines act as bis-nucleophiles, wherein the initial attack occurs at the α-position of enol ether from the ortho position of aniline followed by the subsequent reaction of the amine moiety of aniline at the β-position, leading to the indole framework. This method is simple, obviates the use of expensive/hazardous transition-metal catalysts, and offers a wide range of substrate scope.