97996-84-4Relevant academic research and scientific papers
SYNTHESIS OF BIOLOGICALLY ACTIVE FLUORESCENT PHORBOL ESTERS
Tran, P. L.,Brienne, M. J.,Malthete, J.,Lacombe, L.
, p. 2371 - 2374 (1986)
Pure fluorescent derivatives of 12-O-tetradecanoyl phorbol-13-acetate (TPA), labeled in the tetradecanoyl chain, are synthesized by two ways: 1) from both enantiomers of β-N-dansylaminotetradecanoic acid which requires the resolution of the (+/-)β-aminoacid precursor; 2) from an achiral fluorescent chain derived from 3-azatetradecanoic acid.The new phorbol derivatives retain the main biological activity of TPA.
