
Tetrahedron Letters p. 2371 - 2374 (1986)
Update date:2022-07-30
Topics:
Tran, P. L.
Brienne, M. J.
Malthete, J.
Lacombe, L.
Pure fluorescent derivatives of 12-O-tetradecanoyl phorbol-13-acetate (TPA), labeled in the tetradecanoyl chain, are synthesized by two ways: 1) from both enantiomers of β-N-dansylaminotetradecanoic acid which requires the resolution of the (+/-)β-aminoacid precursor; 2) from an achiral fluorescent chain derived from 3-azatetradecanoic acid.The new phorbol derivatives retain the main biological activity of TPA.
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(1986)