98-18-0

Basic information

• Product Name: 3-Aminobenzenesulfonamide
• Synonyms: 3-amino-benzenesulfonamid;3-aminosulfonylaniline;Benzenesulfonamide, m-amino-;m-Aminobenzenesulphonamide;Metaniilamide;m-sulfamoylaniline;M-AMINOBENZENESULFONAMIDE;METANILAMIDE
• CAS NO: 98-18-0
• Molecular Formula: C₆H₈N₂O₂S
• Molecular Weight: 172.2
• EINECS: 202-646-0
• Product Categories: SULFONAMIDE;Intermediates of Dyes and Pigments;Amines;blocks;Sulfonamides
• Mol File: 98-18-0.mol
• Article Data: 12

Chemical Properties

• Melting Point: 139 °C
• Boiling Point: 420.7 °C at 760 mmHg
• Flash Point: 208.3 °C
• Appearance: /solid
• Density: 1.303 (estimate)
• Vapor Pressure: 2.75E-07mmHg at 25°C
• Refractive Index: 1.6490 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 10.34±0.60(Predicted)
• Water Solubility: 11.96g/L(24 oC)
• CAS DataBase Reference: 3-Aminobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Aminobenzenesulfonamide(98-18-0)
• EPA Substance Registry System: 3-Aminobenzenesulfonamide(98-18-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: OY2200000
• TSCA: Yes
• Hazardous Substances Data: 98-18-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H8N2O2S/c7-5-2-1-3-6(4-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10)

Upstream product

• 127-68-4 sodium 3-nitrobenzenesulfonate 
• 121-51-7 3-nitrobenzenesulphonyl chloride 
• 121-52-8 3-nitrophenylsulfonamide 
• 3887-48-7 3-amino-benzenesulfonyl fluoride; hydrochloride 

Downstream Products

• 146374-16-5 3-amino-benzenesulfonic acid pyrazin-2-ylamide 
• 32548-97-3 Benzene-1,3-disulfonic acid 1-amide 3-dipropylamide 
• 103151-29-7 3-acetoacetylamino-benzenesulfonic acid amide 
• 852711-50-3 N-(3-(aminosulfonyl)phenyl)-4-(trifluoromethoxy)benzamide 
• 952307-40-3 2-cyclohexyl-N-(3-(aminosulfonyl)phenyl)benzamide 
• 1135871-50-9 3-(5-acetyl-furan-2-yl)-benzenesulfonamide 
• 1445879-19-5 N-cyclopropyl-7-(2,4-dimethoxypyrimidin-5-yl)-4-((3-sulfamoylphenyl)amino)quinoline-3-sulfonamide 

Relevant articles and documents

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Preparation of Well-Ordered Mesoporous-Silica-Supported Ruthenium Nanoparticles for Highly Selective Reduction of Functionalized Nitroarenes through Transfer Hydrogenation

MCM-41-type mesoporous silica (OMS-IL) was prepared by using an ionic liquid (1-hexadecyl-3-methylimidazolium bromide) as a template. The XRD and TEM results demonstrated that OMS-IL was more stable than the MCM-41 material. Ru nanoparticles were supported on OMS-IL (Ru/OMS-IL) by impregnating OMS-IL with a RuCl3 aqueous solution, and the resulting material was used for the selective reduction of nitroarenes. The effects of the components of the catalysts and the reaction conditions on the catalytic behavior of the prepared catalysts were investigated in detail. Ru/OMS-IL exhibited high catalytic activity and chemoselectivity for the reduction of various substituted nitroarenes to the corresponding aromatic amines in ethanol with hydrazine hydrate as a hydrogen donor under mild conditions. The Ru/OMS-IL catalysts were highly stable and could easily be recovered by simple filtration over at least six recycling reactions without any observable loss in catalytic performance.

Discovery of a Series of 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-ones as Selective PI3K-δ/γ Inhibitors

Dual inhibition of PI3K-δ and PI3K-γ is an established therapeutic strategy for treatment of hematological malignancies. Reported molecules targeting PI3K-δ/γ selectively are chemically similar and based upon isoquinolin-1(2H)-one or quinazolin-4(3H)-one scaffolds. Here we report a chemically distinct series of potent, selective PI3K-δ/γ inhibitors based on a 5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one scaffold with comparable biochemical potency and cellular effects on PI3K signaling. We envisage these molecules will provide useful leads for development of next-generation PI3K-δ/γ targeting therapeutics.