98-84-0

Usage

Uses

Used in Synthesis:
DL-ALPHA-METHYLBENZYLAMINE is used as a chemical intermediate for the synthesis of various compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its reactivity and compatibility with organic solvents make it a valuable component in the synthesis process.
Used as an Emulsifying Agent:
In the chemical and pharmaceutical industries, DL-ALPHA-METHYLBENZYLAMINE is used as an emulsifying agent to stabilize mixtures of immiscible liquids, such as oil and water. Its solubility in both organic solvents and water allows it to act as a bridge between the two phases, improving the stability and performance of emulsions.

Hazard

Toxic by ingestion.

Safety Profile

Moderately toxic by ingestion andskin contact. A skin and severe eye irritant. When heated to decomposition it emits toxicfumes of NOx.

InChI:InChI=1/C8H11N/c1-7(9)8-5-3-2-4-6-8/h2-7H,9H2,1H3

Upstream product

• 618-36-0 rac-methylbenzylamine 
• 613-91-2 acetophenone oxime 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 98-86-2 acetophenone 

Downstream Products

• 2449-49-2 (+)-D-N,N-dimethyl-α-phenylethylamine 
• 96973-05-6 (-)-N-(D-1-phenylethyl)-N^α-benzoyldidehydrovalylamide 
• 89661-82-5 {(S)-2-(4-Hydroxy-phenyl)-1-[(R)-1-((S)-2-phenyl-1-{[(1-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-ethylcarbamoyl)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester 
• 123492-27-3 [2-((S)-Methyl-phenyl-phosphinoyl)-ethyl]-(1-phenyl-ethyl)-amine 
• 81450-45-5 d-N-(1-phenyl-1-ethyl)pyrazino<2,3-d>-1,2,4-triazolo<4,3-b>pyridazin-6-amine 
• 74145-53-2 D-N,N'-(1-Phenylethyl)-2,2'-(3,6-dioxaoctamethylendioxy)dibenzoesaeurediamid 
• 74145-55-4 D-N,N'-(1-Phenylethyl)-2,2'-(3,6,9-trioxamethylendioxy)dibenzoesaeurediamid 
• 120104-74-7 2-[(E)-Benzyloxyimino]-N-(1-phenyl-ethyl)-acetamide 
• 130288-43-6 (2S,4R)-5-(tert-Butyl-dimethyl-silanyloxy)-2,4-dimethyl-pentanoic acid (1-phenyl-ethyl)-amide 
• 130288-43-6 (2R,4S)-5-(tert-Butyl-dimethyl-silanyloxy)-2,4-dimethyl-pentanoic acid (1-phenyl-ethyl)-amide 
• 120104-82-7 2-Benzyloxyamino-3,3-dimethyl-N-(1-phenyl-ethyl)-butyramide 
• 120104-80-5 2-Benzyloxyamino-hexanoic acid (1-phenyl-ethyl)-amide 
• 2449-49-2 (-)-L-N,N-dimethyl-α-phenylethylamine 
• 89661-82-5 {(S)-2-(4-Hydroxy-phenyl)-1-[(R)-1-((S)-2-phenyl-1-{[(1-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-ethylcarbamoyl)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF CHIRAL AMINES BY ASYMMETRIC HYDROGENATION OF PROCHIRAL OXIMES

There is provided a method for the preparation of an enantiomerically enriched amine by asymmetric hydrogenation of a prochiral oxime.

The evolution of an amine dehydrogenase biocatalyst for the asymmetric production of chiral amines

The reductive amination of ketones to produce chiral amines is an important transformation in the production of pharmaceutical intermediates. Therefore, industrially applicable enzymatic methods that enable the selective synthesis of chiral amines could be very useful. Using a phenylalanine dehydrogenase scaffold devoid of amine dehydrogenase activity, a robust amine dehydrogenase has been evolved with a single two-site library allowing for the direct production of (R)-1-(4-fluorophenyl)-propyl-2-amine from para- fluorophenylacetone with a kcat value of 6.85 s-1 and a KM value of 7.75 mM for the ketone substrate. This is the first example of a highly active amine dehydrogenase capable of accepting aliphatic and benzylic ketone substrates. The stereoselectivity of the evolved amine dehydrogenase was very high (>99.8% ee) showing that high selectivity of the wild-type phenylalanine dehydrogenase was conserved in the evolution process. When paired with glucose/glucose dehydrogenase, NADH cofactor can be effficiently regenerated and the reaction driven to over 93% conversion. The broad specificity, high selectivity, and near complete conversion render this amine dehydrogenase an attractive target for further evolution toward pharmaceutical compounds and subsequent application. Copyright

Synthesis of chiral ionic liquids from natural amino acids

For the first time, chiral imidazolium ionic liquids containing one chiral carbon (10a-c) were synthesized from the natural amino acids by a simple and straight-forward procedure. The characteristics of the chiral ILs are very similar to the popular ionic liquids.