98009-46-2Relevant academic research and scientific papers
Keto-alkyne cyclisation reactions: heterocyclic prostacyclin analogues
Richardson, Kevan A.,Saunders, John,Taylor, Richard J.K.
, p. 1171 - 1174 (1985)
Simple furan, thiophene and pyrrole analogues of prostacyclin have been prepared from readily-available 4-alkvnyl ketones; the cyclohexa[b]-furano-prostacyclin analogue 3 has also been synthesised using the keto-alkyne cyclisation procedure.
The Synthesis of Heteroaromatic Prostacyclin Analogues via Keto Alkyne Cyclisation
Cook, Stuart,Henderson, Douglas,Richardson, Kevan A.,Taylor, Richard J. K.,Saunders, John,Strange, Philip G.
, p. 1825 - 1832 (2007/10/02)
Keto alkyne cyclisation has been used to prepare tetrahydrobenzofurans (4) and (15) but cyclopentafurans are not available by this procedure.Compound (15) has been converted into benzofuran prostacyclin analogues (5) and (6) by extremely short route
