98013-03-7Relevant academic research and scientific papers
NaH-promoted transformation of arylthioureas to aryl-isothioureas by S-allylation and S-benzylation reactions
Liu, Min,Zeng, Meng-Tian,Xu, Wan,Chang, Cai-Zhu,Liu, Xing,Zhu, Hui,Lic, Yue-Sheng,Dong, Zhi- Bing
, p. 165 - 167 (2017)
A series of 16 substituted aryl-isothioureas were prepared in excellent yields (80-97%) by reacting substituted arylthioureas with allyl bromide or substituted benzyl bromides in the presence of NaH in DMSO at room temperature. The substituent variations on the benzyl reactants had a larger effect on the yields than substituent variations on the allyl reactants. The method provides a facile and convenient preparation of some potentially biologically active compounds.
Benzylation of Thioamides and Thioureas with Triethylbenzylammonium Chloride Under Phase Transfer Catalysis
Singh, Paramjit,Aggarwal, Sunil K.,Sarin, Rakesh,Malhotra, Nageshwar,Singh, Harjit
, p. 263 - 265 (2007/10/02)
The reactions of triethylbenzylammonium chloride with thioamides/thioureas under phase transfer catalysis conditions provide mainly S-benzylated products.The reactions have been rationalised and optimum condition worked out to get the maximum yield of the
