98014-60-9Relevant academic research and scientific papers
Stereoselective Synthesis of Piperidines by Iridium-Catalyzed Cyclocondensation
Sandmeier, Tobias,Krautwald, Simon,Carreira, Erick M.
, p. 11515 - 11519 (2017/09/11)
An iridium-catalyzed cyclocondensation of amino alcohols and aldehydes is reported. Intramolecular allylic substitution by an enamine intermediate and subsequent in situ reduction furnishes 3,4-disubstituted piperidines with high enantiospecificity and good diastereoselectivity. The modular approach and the broad functional group tolerance provide access to diverse piperidine derivatives, which were further functionalized to give a versatile set of products.
Stereocontrolled Synthesis of Cis-Fused Hydroisoquinolines by an Intramolecular Diels-Alder Reaction of (Z)-Dienes
Wattanasin, S.,Kathawala, F. G.,Boeckman, R. K.
, p. 3810 - 3815 (2007/10/02)
An efficient stereocontrolled synthesis highly functionalized cis-fused octahydroisoquinolines via an intramolecular Diels-Alder reaction of (Z)-dienes is described.
