98014-60-9Relevant articles and documents
Stereoselective Synthesis of Piperidines by Iridium-Catalyzed Cyclocondensation
Sandmeier, Tobias,Krautwald, Simon,Carreira, Erick M.
, p. 11515 - 11519 (2017/09/11)
An iridium-catalyzed cyclocondensation of amino alcohols and aldehydes is reported. Intramolecular allylic substitution by an enamine intermediate and subsequent in situ reduction furnishes 3,4-disubstituted piperidines with high enantiospecificity and good diastereoselectivity. The modular approach and the broad functional group tolerance provide access to diverse piperidine derivatives, which were further functionalized to give a versatile set of products.