98022-90-3Relevant academic research and scientific papers
Kinetic study of the chlorine transfer from n-chlorosuccinimide to amino compounds
Antelo,Arce,Crugeiras,Parajo
, p. 631 - 636 (2007/10/03)
A kinetic study of the reactions of N-chlorosuccinimide (NCS) with glycine (GIy), sarcosine (Sar), 2-methylalanine (2MA), proline (Pro) and pyrrolidine (Pyr) was carried out. The reactions were found to be first order with respect to both NCS and the amine or amino acid and order - 1 in proton concentration. In order to calculate the experimental activation parameters, the effect of temperature on the reaction rates was studied. The ionic strength and buffer concentration were found to have no effect on the rate constant. A reaction mechanism involving Cl+ transfer from NCS to the amine or amino acid to form an N-chloro compound is proposed.
α-AMINO ACIDS CHLORINATION IN AQUEOUS MEDIA
Armesto, X. L.,Canle L., M.,Santaballa, J. A.
, p. 275 - 284 (2007/10/02)
The reaction of chlorination of α-amino acids for 6 pH 11 has been studied.The reaction is an aliphatic electrophilic substitution, the rate determining step being the transfer of the chlorine atom between the HOCl oxygen and the nitrogen of the α-amino acid free amino group.
