98025-59-3Relevant articles and documents
Synthesis of (1H-1,2,3-Triazol-1-yl)acetic Acid Derivatives
Obushak, M. D.,Pokhodylo, N. T.,Savka, R. D.
, p. 1421 - 1431 (2020/10/02)
Abstract: A convenient synthetic approach to (1H-1,2,3-triazol-1-yl)acetic acid derivatives via the reaction of azidoacetamides with β-ketoesters and acetylacetone is proposed. Based on this strategy, 1,5-disubstituted 1,2,3-triazoles were prepared from available reagents under metal-free conditions. A one-pot protocol for the synthesis of (5-methyl-1H-1,2,3-triazol-1-yl)acetamides derived from N-substituted chloroacetamides is developed.