98049-00-4

Basic information

• Product Name: (1R)-(-)-(1-AMINOPROPYL)PHOSPHONIC ACID
• Synonyms: (R)-(-)-(1-AMINOPROPYL)PHOSPHONIC ACID;(R)-(1-AMINOPROPYL)PHOSPHONIC ACID;(1R)-(-)-(1-AMINOPROPYL)PHOSPHONIC ACID;D-1-AMINO-PROPYLPHOSPHONIC ACID;H-D-APRP(O)-(OH)2;H-D-ABU(2)P-(OH)2;(R)-(1-Aminopropyl)phosphonic acid,99%
• CAS NO: 98049-00-4
• Molecular Formula: C3H10NO3P
• Molecular Weight: 139.09
• Product Categories: Chiral Building Blocks;Organic Building Blocks;Phosphonic/Phosphinic Acids
• Mol File: 98049-00-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 265-269 °C(lit.)
• Boiling Point: 311.9°Cat760mmHg
• Flash Point: 142.4°C
• Appearance: /
• Density: 1.373g/cm³
• Vapor Pressure: 0.00012mmHg at 25°C
• Refractive Index: 1.492
• CAS DataBase Reference: (1R)-(-)-(1-AMINOPROPYL)PHOSPHONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (1R)-(-)-(1-AMINOPROPYL)PHOSPHONIC ACID(98049-00-4)
• EPA Substance Registry System: (1R)-(-)-(1-AMINOPROPYL)PHOSPHONIC ACID(98049-00-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 98049-00-4(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

InChI:InChI=1/C3H10NO3P/c1-2-3(4)8(5,6)7/h3H,2,4H2,1H3,(H2,5,6,7)/t3-/m1/s1

Upstream product

• 97147-68-7 dimethyl 1-aminopropylphosphonate 
• 146098-97-7 (3aR,7aR)-2-propyl-<3a,4,5,6,7,7a-octahydro-1,3-dimethyl-1,3,2-benzodiazaphosphole>-2-oxide 
• 132008-92-5 ((3aR,7aR)-1,3-Dimethyl-2-oxo-octahydro-2λ⁵-benzo[1,3,2]diazaphosphol-2-ylmethyl)-[1,3]dithiolan-2-ylidene-amine 
• 75-03-6 ethyl iodide 

Relevant articles and documents

Conversion of nitriles to 1-aminophosphonic acids and preparation of phosphahomocysteines of high enantiomeric excess

A variety of nitriles was reduced to diisobutylaluminum salts of aldimines, to which diisopropyl phosphite was added. The corresponding 1-aminophosphonates were either deprotected to give racemic 1-aminophosphonic acids or reacted with Boc2O to yield N-Boc-protected 1-aminophosphonates. The enantiomers of 2-benzylthio-1-(t-butoxycarbonylamino)propylphosphonate were obtained from the racemate by chiral HPLC and converted to phosphonic acid analogs of (R)- and (S)-homocysteine, (R)- and (S)-2-aminobutyric acid and (S)-methionine, all of ee >97% as determined by chiral HPLC.

A simple and general method for the asymmetric synthesis of α-aminophosphonic acids

A simple and general method for the asymmetric synthesis of α-aminophosphonic acids is described. A chiral phosphonate prepared in one step from R-(-)-phenylglycinol was alkylated with good diastereoselectivity using different electrophiles.