98050-72-7

Basic information

• Product Name: 5-Pyrimidinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, ethyl ester
• CAS NO: 98050-72-7
• Molecular Formula: C15H17N3O4
• Molecular Weight: 303.318
• Mol File: 98050-72-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-Pyrimidinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, ethyl ester(98050-72-7)
• EPA Substance Registry System: 5-Pyrimidinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, ethyl ester(98050-72-7)

Safety Data

• Hazardous Substances Data: 98050-72-7(Hazardous Substances Data)

Upstream product

• 39562-16-8 ethyl 2-(3-nitrophenylmethylene)-3-oxobutanoate 
• 124-42-5 acetamidine hydrochloride 
• 99-61-6 3-nitro-benzaldehyde 
• 141-97-9 ethyl acetoacetate 
• 98064-08-5 5-(ethoxycarbonyl)-6-hydroxy-2,6-dimethyl-4-(m-nitrophenyl)-1,4,5,6-tetrahydropyrimidine 
• 39562-16-8 ethyl (Z)-2-(3-nitrobenzylidene)-3-oxobutanoate 

Downstream Products

• 98050-84-1 3,5-bis(ethoxycarbonyl)-2,6-dimethyl-4-(m-nitrophenyl)-3,4-dihydropyrimidine 
• 98050-91-0 1-Acetyl-2,4-dimethyl-6-(3-nitro-phenyl)-1,6-dihydro-pyrimidine-5-carboxylic acid ethyl ester 
• 143996-62-7 2,4-Dimethyl-6-(3-nitro-phenyl)-pyrimidine-5-carboxylic acid ethyl ester 

Relevant articles and documents

Studies on cerebral protective agents. I. Novel 4-arylpyrimidine derivatives with anti-anoxic and anti-lipid peroxidation activities

Novel 4-arylpyrimidine derivatives were synthesized by the oxidation of 4-aryl-1,4-dihydropyrimidines, and their effects on anti-anoxic (AA) activity in mice and anti-lipid peroxidation (ALP) activity in rat brain mitochondria were investigated. Among these compounds, ethyl 6-methyl-2-phenyl-4-(4-pyridyl)-5-pyrimidinecarboxylate (4b) has AA activity (10mg/kg, i.p.) and ethyl 6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxylate (4f) has ALP activity (73% inhibition at 10-5 g/ml). The latter compound (100mg/kg, i.p.) was also effective on arachidonate-induced cerebral edema in rats with comparable potency to that of vitamin E.