98061-25-7

Upstream product

• 109-09-1 2-chloropyridine 
• 23112-96-1 (2,6-dimethoxyphenyl)boronic acid 
• 67-56-1 methanol 
• 1008-89-5 2-phenylpyridine 
• 109-04-6 2-bromo-pyridine 
• 5029-67-4 2-iodopyridine 
• 151-10-0 1,3-Dimethoxybenzene 

Downstream Products

• 1008-89-5 2-phenylpyridine 
• 879005-55-7 C₃₇H₃₅N₃O₈ 
• 879005-46-6 2-(2,6-dihydroxyphenyl)pyridine 
• 334977-46-7 1,3-dimethoxy-2-(pyrid-2-yl)-4-bromobenzene 

Relevant academic research and scientific papers

Palladium-catalyzed selective ortho C–H alkoxylation at 4-aryl of 1, 4-disubstituted 1, 2, 3-triazoles

The ortho- C–H bonds at C(4)-aryl of 1, 4-disubstituted 1, 2, 3-triazoles were regioselectively alkoxylated in good to excellent yields with under the directing of the triazole ring. Some products were found to exhibit strong antifungal capacity to fight against root-rot disease of Panax notoginseng by testing the minimum inhibitory concentration (MIC).

Delineating the Role of Substituents on the Coordination Behavior of Aroylhydrazone Ligands in PdII Complexes and their Influence on Suzuki–Miyaura Coupling in Aqueous Media

Reactions of piperonal aroylhydrazone ligands (HL1–HL4) with [PdCl2(PPh3)2] in CH3OH and CHCl3 afforded four new Pd(II) complexes (1–4) featuring diverse coordination behaviors. These complexes 1–4 were fully characterized by elemental analyses, UV/Visible, FT-IR and 1H/13C NMR spectra. The variant coordination modes of piperonal aroylhydrazone ligands with Pd(II) ion in these complexes were unambiguously confirmed by single-crystal XRD study. Though the ligands HL1–HL4 are of similar nature, one of them (HL4) possessing an electron withdrawing nitro group as substitution in the peripheral part of the hydrazone displayed an uncommon ligation towards the palladium ion. An experimentally observed molecular architects were in turn rationalized by density functional theory (DFT) calculations as well as natural bonding analysis (NBO). All these Pd(II) complexes were evaluated for their catalytic potential towards Suzuki–Miyaura cross-coupling reaction of sterically congested arylboronic acids with (hetero)arylhalides under an open-flask conditions in aqueous media with low catalyst loading. Advantageously, the selected catalyst was active up to five cycles without significant loss in activity.

Palladium-catalyzed ortho-alkoxylation of 2-aryl-1,2,3-triazoles

Palladium-catalyzed alkoxylation of 2-aryl-1,2,3-triazoles was described in the presence of various groups in the aromatic rings. In addition, some other directing groups of heterocycles containing nitrogen were explored.

Structurally simple pyridine N-oxides as efficient organocatalysts for the enantioselective allylation of aromatic aldehydes

A series of structurally simple pyridine N-oxides have readily been assembled from inexpensive amino acids and tested as organocatalysts in the allylation of aldehydes with allyl(trichloro)silane to afford homoallylic alcohols. (S)-Proline-based catalysts

Palladium catalyzed Suzuki-Miyaura coupling with aryl chlorides using a bulky phenanthryl N-heterocyclic carbene ligand

A novel bis-phenanthryl N-heterocyclic carbene (NHC) based palladium acetate catalyst was effective for the coupling of various aryl and vinyl chlorides with organoboron compounds. N,N-Bis-(2,9-dicyclohexyl-10-phenanthryl)- 4,5-dihydroimidazolium chloride 8 (H2ICP·HCl) with Pd(OAc)2 and KF·18-c-6 in THF at room temperature gave Suzuki-Miyaura coupling of aryl and vinyl chorides, including unactivated and di-ortho substituted substrates in high yields. Hindered tri- and tetra-ortho substituted products were also efficiently produced. Benzyl chloride was also found to be a useful coupling partner and trimethylboroxine was used to give methylated products. The effect of ligand, base, temperature, solvent, and reaction time are reported along with various substrates including halides and triflates.

Electron-deficient nitrogen heterocycle-substituted fluorescein dyes

The invention provides compositions electron-deficient nitrogen heterocycle-substituted fluorescein dyes and methods in which the dyes are conjugated to substrates and used as detection labels in molecular biology experiments. The electron-deficient nitro

Photo-Arylation. IV. Synthesis of 2-Arylpyridines by Photo-Reaction of 2-Iodopyridine with Substituted Benzenes

Photolysis of a mixture of 2-iodopyridine and a variety of substituted benzenes in dichloromethane afforded the corresponding 2-arylpyridines as isomeric mixtures.Based on the isomer distributions of the products and the formation of 2-chloropyridine as a by-product, the reactivity of 2-iodopyridine in the present reaction was suggested to be electrophilic in character.Keywords - arylpyridine; 2-pyridinylation; photo-arylation; photolysis; 2-iodopyridine; homolytic aromatic substitution