98079-52-8 Usage
Description
Different sources of media describe the Description of 98079-52-8 differently. You can refer to the following data:
1. Lomefloxacin hydrochloride is the hydrochloride form of Lomefloxacin. Lomefloxacin is a bactericidal fluoroquinolone agent that is active against gram-negative and gram-positive organisms. Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited. Lomefloxacin can be used to treat many kinds of infections such as respiratory, urinary tract, obstetric, gynaecological, joint, skin, oral, ear, nose, throat and eye infections. Compared with other quinolone antibacterial drugs, lomefloxacin has certain advantages such as convenient administration and no necessity of theophylline dosage adjustment.
2. Lomefloxacin is an orally bioavailable, broad-spectrum fluoroquinolone antibiotic. In vitro, it inhibits growth of N. gonorrhoeae, E. coli, K. pneumoniae, P. vulgaris, S. epidermidis, and M. morganii (MIC90s = 0.1, 0.39, 0.39, 0.39, 0.39, and 0.78 μg/ml, respectively). It also inhibits growth of S. aureus and methicillin-resistant S. aureus (MRSA; MIC90 = 3.13 μg/ml for both) and of H. influenzae and ampicillin-resistant H. influenzae (MIC90 = 0.1 μg/ml for both). In vivo, lomefloxacin inhibits the growth of P. mirabilis, E. coli, K. pneumoniae, and S. aureus (ED50s = 1.39, 1.45, 1.78, and 6.66 mg/kg, respectively) in mouse models of systemic infection. It inhibits bacterial DNA gyrase, thereby inhibiting DNA synthesis and bacterial growth. Formulations containing lomefloxacin have been used in the treatment of bronchitis and urinary tract bacterial infections.
Chemical Properties
White powder with no smell, bitter taste
Originator
Foxil,Sarabhai Chemicals,India
Definition
ChEBI: The hydrochloride salt of lomefloxacin. It is administered by mouth to treat bacterial infections including bronchitis and urinary tract infections. It is also used topically as eye drops for the treatment of bacterial conjunctivitis, and as ear drops for
he treatment of otitis externa and otitis media.
Brand name
Maxaquin (Pharmacia).
References
Wadworth, A. N., and K. L. Goa. "Lomefloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. " Drugs 42.6(1991): 1018-60.
Symonds, W. T., and D. E. Nix. "Lomefloxacin and temafloxacin: two new fluoroquinolone antimicrobials." Clin Pharm 11.9(1992): 753-66.
Check Digit Verification of cas no
The CAS Registry Mumber 98079-52-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,0,7 and 9 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 98079-52:
(7*9)+(6*8)+(5*0)+(4*7)+(3*9)+(2*5)+(1*2)=178
178 % 10 = 8
So 98079-52-8 is a valid CAS Registry Number.
InChI:InChI=1/C17H19F2N3O3.ClH/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22;/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25);1H
98079-52-8Relevant articles and documents
Preparation method of lomefloxacin hydrochloride
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Paragraph 0025-0029, (2019/12/25)
The invention discloses a preparation method of lomefloxacin hydrochloride. The preparation method comprises the steps: with a lomefloxacin hydrochloride cyclization material as a starting raw material, the lomefloxacin hydrochloride finished product is obtained through ethylation reaction, hydrolysis reaction, condensation reaction with 2-methylpiperazine and salt formation; an ethylation reagentused in the ethylation reaction is bromoethane, and bromoethane is directly added; the ethylation reaction temperature is further divided into two sections, firstly, reaction is carried out for 2 h at the temperature of 80-90 DEG C, and then reaction is carried out for 2 h at the temperature of 100-105 DEG C; the hydrolysis reaction is carried out in the presence of glacial acetic acid and purified water. In the ethylation, the reaction yield can be greatly improved by adjusting the reaction temperature; the hydrolysis reaction adopts a part of purified water instead of glacial acetic acid, the yield not only can be guaranteed, but also the production cost is greatly reduced and the discharge of three wastes is reduced.
