- Lomefloxacin
- Lomefloxacin hydrochloride
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| Name |
Lomefloxacin hydrochloride |
EINECS | 627-337-1 |
| CAS No. | 98079-52-8 | Density | N/A |
| PSA | 74.57000 | LogP | 2.99170 |
| Solubility | N/A | Melting Point |
290-300 °C |
| Formula | C17H20ClF2N3O3 | Boiling Point | 542.7 °C at 760 mmHg |
| Molecular Weight | 387.814 | Flash Point | 282 °C |
| Transport Information | N/A | Appearance | White powder with no smell, bitter taste |
| Safety | Risk Codes | 22 | |
| Molecular Structure |
|
Hazard Symbols |
 Xn
|
| Synonyms |
3-Quinolinecarboxylicacid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-,monohydrochloride (9CI);Alkaflox;Bareon;Chimono;Lomebact;3-Quinolinecarboxylicacid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-,hydrochloride (1:1);Lomflox;Lomitas;Lomoxin;Maxaquin;Mazaquin;Orchacin;Uniquin; |
Lomefloxacin hydrochloride Chemical Properties
IUPAC Name: 1-Ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid hydrochloride
Molecular Formula: C17H20ClF2N3O3
Molecular Weight: 387.808806 g/mol
H-Bond Donor: 3
H-Bond Acceptor: 8
Canonical SMILES: CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O.Cl
InChI: InChI=1S/C17H19F2N3O3.ClH/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22;/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25);1H
Classification Code: Antibacterial; Drug / Therapeutic Agent; Reproductive Effect
Product Categories: Antibiotics for Research and Experimental Use;Biochemistry; Quinolones (Antibiotics for Research and Experimental Use); Intermediates & Fine Chemicals; Pharmaceuticals; Lomefloxacin
Flash Point: 282 °C
Melting Point: 290-300 °C
Boiling Point: 542.7 °C at 760 mmHg
Enthalpy of Vaporization: 86.39 kJ/mol
Vapour Pressure: 1.31E-12 mmHg at 25 °C
Storage Temperatureof Lomefloxacin hydrochloride (CAS NO.98079-52-8): -20 °C
Lomefloxacin hydrochloride Uses
Lomefloxacin hydrochloride (CAS NO.98079-52-8) is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery.
Lomefloxacin hydrochloride Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | 50mg/kg (50mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 32, Pg. 1288, 1990. | |
| mouse | LD50 | intravenous | 253mg/kg (253mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Chemotherapy Vol. 36(Suppl, |
| mouse | LD50 | oral | 1608mg/kg (1608mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Chemotherapy Vol. 36(Suppl, |
| mouse | LD50 | subcutaneous | 995mg/kg (995mg/kg) | Zhongguo Kangshengsu Zazhi. Chinese Journal of Antibiotics. Vol. 19, Pg. 154, 1994. | |
| rat | LD50 | intravenous | 328mg/kg (328mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Chemotherapy Vol. 36(Suppl, |
| rat | LD50 | oral | 1556mg/kg (1556mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Chemotherapy Vol. 36(Suppl, |
| rat | LD50 | subcutaneous | 1637mg/kg (1637mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Chemotherapy Vol. 36(Supp |
Lomefloxacin hydrochloride Safety Profile
Hazard Codes: 
Xn
Risk Statements: 22
R22:Harmful if swallowed.
WGK Germany: 3
RTECS of Lomefloxacin hydrochloride (CAS NO.98079-52-8): VB1997500
Lomefloxacin hydrochloride Specification
Lomefloxacin hydrochloride (CAS NO.98079-52-8), its Synonyms are (+-)-1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, monohydrochloride ; Bareon ; Lomefloxacin HCl ; Maxaquin ; 3-Quinolinecarboxylic acid, 1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-, monohydrochloride ; 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, monohydrochloride, (+-)- . It is white powder with no smell, bitter taste.
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