98081-76-6

Upstream product

• 1816-92-8 Methyl azidoacetate 
• 104-88-1 4-chlorobenzaldehyde 
• 7560-44-3 methyl 4-chlorocinnamate 

Downstream Products

• 98081-84-6 6-chloro-2-methoxycarbonylindole 
• 1372411-86-3 methyl 4-(4-chloro-phenyl)-5-hydroxy-1-oxo-2,5-dihydro-1H-benzo[c]azepine-3-carboxylate 
• 1372412-01-5 methyl 4-(4-chloro-phenyl)-1,5-dioxo-2,5-dihydro-1H-benzo[c]azepine-3-carboxylate 
• 1584221-42-0 C₁₇H₁₄ClNO₂ 
• 1584221-43-1 C₁₆H₁₄ClNO 
• 1584221-45-3 C₁₆H₁₂ClNO 
• 1584221-46-4 C₂₃H₁₉ClN₂O₂S 
• 1584221-47-5 C₂₃H₂₁ClN₂O₂S 
• 1529806-92-5 9-benzyl-7-chloro-4'-methyl-1',2-ditosyl-1,1',2,3,5',9-hexa-hydrospiro[pyrido[3,4-b]indole-4,2'-pyrrole] 
• 1529806-73-2 N-((1-benzyl-6-chloro-1H-indol-2-yl)methyl)-4-methyl-N-(3-(2-methyl-1-tosylaziridin-2-yl)-prop-2-ynyl)benzenesulfonamide 
• 1621106-11-3 methyl 4-(4-chlorophenyl)-3-(p-tolyl)isoxazole-5-carboxylate 
• 186700-30-1 methyl 3-(4-chlorophenyl)-2-hydroxypropanoate 
• 98081-81-3 methyl 2-(4-chlorophenyl)-2H-azirine-3-carboxylate 

Relevant academic research and scientific papers

Synthesis of 3,4,5-trisubstituted isoxazoles by the 1,3-dipolar cycloaddition reaction of α-azido acrylates and aromatic oximes

A novel, one-pot, cascade reaction sequence featuring the 1,3-dipolar cycloaddition reaction of α-azido acrylates and aromatic oximes was developed. This procedure provides an efficient, straightforward and metal-free method for the synthesis of 3,4,5-trisubstituted isoxazoles under mild reaction conditions.

Gold(I)-catalyzed rearrangement of alkynylaziridine indoles for the synthesis of spiro-tetrahydro-β-carbolines

Functionalized spiro-tetrahydro-β-carbolines were formed by an efficient gold(I)-catalyzed rearrangement reaction of alkynylaziridine indoles. The reaction involved a Friedel-Crafts type intramolecular reaction of alkynylaziridine indoles, following by hydroamination of aminoallene intermediate.

Extending the versatility of the Hemetsberger-Knittel indole synthesis through microwave and flow chemistry

Microwave, flow and combination methodologies have been applied to the synthesis of a number of substituted indoles. Based on the Hemetsberger-Knittel (HK) process, modifications allow formation of products rapidly and in high yield. Adapting the methodology allows formation of 2-unsubstituted indoles and derivatives, and a route to analogs of the antitumor agent PLX-4032 is demonstrated. The utility of the HK substrates is further demonstrated through bioconjugation and subsequent ring closure and via Huisgen type [3+2] cycloaddition chemistry, allowing formation of peptide adducts which can be subsequently labeled with fluorine tags.

[Fe(F20TPP)Cl] catalyzed intramolecular C-N bond formation for alkaloid synthesis using aryl azides as nitrogen source

The syntheses of alkaloids including indoles, indolines, tetrahydroquinolines, dihydroquinazolinones and quinazolinones have been accomplished in moderate to excellent yields via [Fe(F20TPP)Cl] catalyzed intramolecular C-N bond formation using aryl azides as nitrogen source.