98119-89-2

Usage

Uses

Used in Pharmaceutical Industry:
Benzene, 2-nitro-1,3-bis(phenylthio)is used as an intermediate in the synthesis of 9-Chloro Quetiapine (C366040), which is an impurity of Quetiapine hemifumarate (Q510000). Quetiapine hemifumarate is a dibenzothiazepine antipsychotic medication used in the treatment of schizophrenia. The synthesis of this intermediate plays a crucial role in the production of effective antipsychotic drugs, contributing to the management and treatment of mental health disorders.

Upstream product

• 19064-24-5 2,6-difluoro-1-nitrobenzene 
• 108-98-5 thiophenol 
• 601-88-7 2,6-dichloronitrobenzene 

Downstream Products

• 1271825-55-8 2,6-bis(phenylsulfanyl)aniline 
• 1271825-58-1 (2-azido-1,3-phenylene)bis(phenylsulfane) 
• 1271825-62-7 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine 

Relevant academic research and scientific papers

2,6-Bis(arylsulfonyl)anilines as fluorescent scaffolds through intramolecular hydrogen bonds: Solid-state fluorescence materials and turn-on-type probes based on aggregation-induced emission

A series of 2,6-bis[aryl(alkyl)sulfonyl]anilines were synthesized by nucleophilic aromatic substitution of 2,6-dichloronitrobenzene with various aryl or alkyl thiolates (benzyl-, phenyl-, 2-naphthyl-, and 2-aminophenyl thiolate), followed by hydrogenation

Improved Inhibitors of Trypanothione Reductase by Combination of Motifs: Synthesis, Inhibitory Potency, Binding Mode, and Antiprotozoal Activities

Trypanothione reductase (TR) is an essential enzyme in the trypanothione-based redox metabolism of trypanosomatid parasites. This system is absent in humans and, therefore, offers a promising target for the development of selective new drugs against Afric